@misc{10481/69997,
year = {2021},
month = {6},
url = {http://hdl.handle.net/10481/69997},
abstract = {Background: Autoimmune diseases are heterogeneous pathologies with difficult
diagnosis and few therapeutic options. In the last decade, several omics studies have
provided significant insights into the molecular mechanisms of these diseases. Nevertheless,
data from different cohorts and pathologies are stored independently in public
repositories and a unified resource is imperative to assist researchers in this field.
Results: Here, we present Autoimmune Diseases Explorer (https:// adex. genyo. es), a
database that integrates 82 curated transcriptomics and methylation studies covering
5609 samples for some of the most common autoimmune diseases. The database
provides, in an easy-to-use environment, advanced data analysis and statistical
methods for exploring omics datasets, including meta-analysis, differential expression
or pathway analysis.
Conclusions: This is the first omics database focused on autoimmune diseases. This
resource incorporates homogeneously processed data to facilitate integrative analyses
among studies.},
organization = {FEDER/Junta de Andalucia-Consejeria de Economia y Conocimiento	CV20-36723},
organization = {Consejeria de Salud	PI-0173-2017},
organization = {EU/EFPIA Innovative Medicines Initiative Joint Undertaking PRECISESADS	115565},
organization = {Ministerio de Economia, Industria y Competitividad},
publisher = {BMC},
keywords = {Autoinmune disease},
keywords = {Database},
keywords = {GEO},
keywords = {Transcriptomics},
keywords = {Epigenomics},
keywords = {Curation},
keywords = {Dataset},
keywords = {Interferon signature},
keywords = {Gene expression},
keywords = {Meta-analysis},
title = {A comprehensive database for integrated analysis of omics data in autoimmune diseases},
doi = {10.1186/s12859-021-04268-4},
author = {Martorell Marugán, Jordi and López Domínguez, Raúl and García Moreno, Adrián and Toro Domínguez, Daniel and Villatoro García, Juan Antonio and Barturen, Guillermo and Alarcón Riquelme, Marta Eugenia and Carmona Sáez, Pedro},
}