@misc{10481/69603,
year = {2021},
url = {http://hdl.handle.net/10481/69603},
abstract = {Background and aims: Vitamin D inadequacy may be involved in the mechanisms of
SARS‐CoV‐2 infection and in potential risk factors for disease propagation or control of coronavirus
disease 2019 (COVID‐19). This study assessed a short‐term evolution of vitamin D status and its
influence upon different clinical parameters in critically ill patients with COVID‐19. Methods: A
prospective analytical study in which 37 critically ill volunteers between 41 and 71 years of age with
COVID‐19 were evaluated at baseline and three days of intensive care unit (ICU) stay. 25‐OH‐D3
and 25‐OH‐D2 were analyzed by liquid chromatography–tandem mass spectrometry and total 25‐
OH‐D levels were calculated as the sum of both. Results: All patients presented low 25‐OH‐D levels
at baseline, decreasing total 25‐OH‐D (p = 0.011) mainly through 25‐OH‐D2 (p = 0.006) levels during
ICU stay. 25‐OH‐D2 levels decreased a mean of 41.6% ± 89.6% versus 7.0% ± 23.4% for the 25‐OH‐
D3 form during the ICU stay. Patients who did not need invasive mechanical ventilation presented
higher levels of 25‐OH‐D2 at baseline and follow‐up. Lower 25‐OH‐D and 25‐OH‐D3 levels were
associated with higher D‐dimer at baseline (p = 0.003; p = 0.001) and at follow up (p = 0.029), higher
procalcitonin levels (p = 0.002; p = 0.018) at follow up, and lower percentage lymphocyte counts (p =
0.044; p = 0.040) during ICU stay. Conclusions: Deficient vitamin D status in critical patients was
established at the admission and further worsened after three days of stay. Lower vitamin D levels
were related to key altered clinical and biochemical parameters on patients with SARS‐CoV‐2 infec‐
tion. Given the different response of the 25‐OH‐D3 and 25‐OH‐D2 forms, it would be useful to mon‐
itor them on the evolution of the critically ill patient.},
organization = {FIS Projects from Carlos III Health Institute
[REF. PI10/1993]},
organization = {Spanish Ministry of Education},
publisher = {MDPI},
keywords = {Coronavirus disease 2019},
keywords = {SARS‐CoV‐2},
keywords = {Vitamin D},
keywords = {Critical care},
keywords = {Intensive care patient},
title = {Bad Prognosis in Critical Ill Patients with COVID‐19 during Short‐Term ICU Stay Regarding Vitamin D Levels},
doi = {10.3390/nu13061988},
author = {Herrera Quintana, Lourdes María and Gamarra Morales, Yenifer and Vázquez Lorente, Héctor and Molina López, Jorge and Castaño Pérez, José and Machado Casas, Juan Francisco and Coca Zúñiga, Ramón and Pérez Villares, José Miguel and Planells Del Pozo, Elena María},
}