@misc{10481/69512,
year = {2021},
url = {http://hdl.handle.net/10481/69512},
abstract = {What are the biomechanical implications in the dynamics and evolution of a growing solid
tumor? Although the analysis of some of the biochemical aspects related to the signaling pathways
involved in the spread of tumors has advanced notably in recent times, their feedback with the
mechanical aspects is a crucial challenge for a global understanding of the problem. The aim of this
paper is to try to illustrate the role and the interaction between some evolutionary processes (growth,
pressure, homeostasis, elasticity, or dispersion by flux-saturated and porous media) that lead to
collective cell dynamics and defines a propagation front that is in agreement with the experimental
data. The treatment of these topics is approached mainly from the point of view of the modeling and
the numerical approach of the resulting system of partial differential equations, which can be placed
in the context of the Hele-Shaw-type models. This study proves that local growth terms related to
homeostatic pressure give rise to retrograde diffusion phenomena, which compete against migration
through flux-saturated dispersion terms.},
organization = {MINECO-Feder (Spain) research grant numbers RTI2018-098850-B-I00 (J.C., J.S.) & EQC2018-004508-P (B.B., J.M.)},
organization = {Junta de Andalucía (Spain)
Projects PY18-RT-2422 (J.C., J.S.), A-FQM-311-UGR18 (J.C., J.S.) & IE2017-5537 (B.B., J.M.)},
organization = {Instituto de Salud Carlos III, project number DTS17/00087 (J.M., J.S.)},
organization = {Ministry of Science, Innovation and Universities of Spain, project numbers DPI2017-85359-R (B.B.,
J.M.) & PID2019-106947RA-C22 (B.B., J.M.)},
organization = {Consejería de Economía, Conocimiento, Empresas
y Universidad and European Regional Development Fund (ERDF), ref. SOMM17/6109/UGR (J.C.,
J.M., J.S.)},
organization = {Ministry of Science, Innovation and Universities of
Spain, FPU2017/01415},
publisher = {MDPI},
keywords = {Cell motility},
keywords = {Flux-saturated},
keywords = {Hele-Shaw model},
keywords = {Mathematical modelling},
keywords = {Mechanical feedback},
keywords = {Numerical simulations},
keywords = {Porous media},
keywords = {Tumor dynamics},
title = {Modeling Interactions among Migration, Growth and Pressure in Tumor Dynamics},
doi = {10.3390/math9121376},
author = {Blanco Besteiro, Beatriz and Campos Rodríguez, Juan and Juan, Melchor and Soler Vizcaino, Juan Segundo},
}