@misc{10481/69469,
year = {2021},
month = {6},
url = {http://hdl.handle.net/10481/69469},
abstract = {Purines are ubiquitous structures in cell biology involved in a multitude of cellular
processes, because of which substituted purines and analogs are considered
excellent scaffolds in drug design. In this study, we explored the key structural
features of a purine‐based proapoptotic hit, 8‐tert‐butyl‐9‐phenyl‐6‐benzyloxy‐9Hpurine
(1), by setting up a library of 6‐alkoxy purines with the aim of elucidating the
structural requirements that govern its biological activity and to study the cell
selectivity of this chemotype. This was done by a phenotypic screening approach
based on cell cycle analysis of a panel of six human cancer cell lines, including T cell
leukemia Jurkat cells. From this study, two derivatives (12 and 13) were identified
as Jurkat‐selective proapoptotic compounds, displaying superior potency and cell
selectivity than hit 1.},
organization = {Instituto de Salud Carlos III

Spanish Government

European Commission

RTC-2017-6620},
organization = {Ministerio de Educacion, Cultura y Deporte 

FPU 14/00818},
publisher = {Wiley-VCH Verlag GmbH},
keywords = {Anticancer drugs},
keywords = {Apoptosis},
keywords = {Leukemia},
keywords = {Phenotypic screening},
keywords = {Purine analogs},
title = {Synthesis and screening of 6‐alkoxy purine analogs as cell type‐selective apoptotic inducers in Jurkat cells},
doi = {10.1002/ardp.202100095},
author = {Lorente Macías, Álvaro and Iáñez García, Inmaculada and Jiménez López, M. Carmen and Benítez Quesada, Manuel and Torres Rusillo, Sara and Díaz Mochón, Juan José and Molina Pineda Infantas, Ignacio Jesús and Pineda De Las Infant Y Villatoro, María José},
}