@misc{10481/69271,
year = {2021},
month = {6},
url = {http://hdl.handle.net/10481/69271},
abstract = {BAFF, APRIL and BAFF-R are key proteins involved in the development of B-lymphocytes and
autoimmunity. Additionally, BAFF, APRIL and BAFFR polymorphisms were associated with immunemediated
conditions, being BAFF GCTGT>A a shared insertion-deletion genetic variant for several
autoimmune diseases. Accordingly, we assessed whether BAFF, APRIL and BAFFR represent
novel genetic risk factors for Immunoglobulin-A vasculitis (IgAV), a predominantly B-lymphocyte
inflammatory condition. BAFF rs374039502, which colocalizes with BAFF GCTGT>A, and two
tag variants within APRIL (rs11552708 and rs6608) and BAFFR (rs7290134 and rs77874543) were
genotyped in 386 Caucasian IgAV patients and 806 matched healthy controls. No genotypes or alleles
differences were observed between IgAV patients and controls when BAFF, APRIL and BAFFR variants
were analysed independently. Likewise, no statistically significant differences were found in the
genotype and allele frequencies of BAFF, APRIL or BAFFR when IgAV patients were stratified according
to the age at disease onset or to the presence/absence of gastrointestinal (GI) or renal manifestations.
Similar results were disclosed when APRIL and BAFFR haplotypes were compared between IgAV
patients and controls and between IgAV patients stratified according to the clinical characteristics mentioned above. Our results suggest that BAFF, APRIL and BAFFR do not contribute to the genetic
network underlying IgAV.},
organization = {European Union FEDER fund
	RD16/0012/0014},
organization = {H2020 Programme
	734899},
organization = {Health Ministry},
organization = {Servicio Cántabro de Salud},
organization = {Servizo Galego de Saude},
organization = {European Commission

PI18/00042	EC},
organization = {Research Executive Agency

	REA},
organization = {Instituto de Salud Carlos III

CP16/00033,PI17/00409	ISCIII},
organization = {European Social Fund

CM20/00006,RD16/0012/0009	ESF},
organization = {European Regional Development Fund

	ERDF},
organization = {Instituto de Investigación Marqués de Valdecilla

PREVAL 18/01	IDIVAL},
organization = {Servicio Gallego de Salud
SERGAS},
publisher = {Springer Nature},
title = {BAFF, APRIL and BAFFR on the pathogenesis of Immunoglobulin‑A vasculitis},
doi = {10.1038/s41598-021-91055-z},
author = {Prieto‑Peña, Diana and Ortego Centeno, Norberto},
}