@misc{10481/69047,
year = {2021},
url = {http://hdl.handle.net/10481/69047},
abstract = {(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and
methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism;
(2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data
from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results:
318,686 pre- and postmenopausal women were followed between enrolment in 1992–2000 and
December 2013–December 2015. Dietary MGD intakes were estimated at baseline through foodfrequency questionnaires. Multivariable Cox proportional hazards regression models were used
to quantify the association between dietary intake of MGDs, measured both as a calculated score
based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone
receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of
14.1 years, 13,320 women with malignant BC were identified. No associations were found between
dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped
relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse
association for intakes up to 350 µg/day compared to a reference intake of 205 µg/day. No statistically
significant differences in the associations were observed by hormone receptor status, menopausal
status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association
between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped
trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify
this association.},
organization = {Research Foundation Flanders (FWO,
189019N)},
organization = {Research Foundation Flanders (FWO, V427019N)},
organization = {International Agency for Research on Cancer
(IARC)},
organization = {Department of Epidemiology and Biostatistics, School of Public Health,
Imperial College London},
organization = {NIHR Imperial
Biomedical Research Center (BRC)},
organization = {Danish Cancer Society
(Denmark)},
organization = {Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education
Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France)},
organization = {German
Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam
Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany)},
organization = {Associazione
Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council
(Italy)},
organization = {Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry
(NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland),
World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands)},
organization = {Health Research
Fund (FIS)—Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucía, Asturias,
Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology—ICO (Spain)},
organization = {Swedish
Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden)},
organization = {Cancer Research UK (14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), Medical Research
Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford), (United Kingdom)},
publisher = {MDPI},
keywords = {Breast cancer},
keywords = {Folate},
keywords = {Choline},
keywords = {Betaine},
keywords = {Methionine},
keywords = {EPIC},
title = {Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)},
doi = {10.3390/nu13061843},
author = {Van Puyvelde, Heleen and Sánchez Pérez, María José},
}