@misc{10481/69001,
year = {2021},
url = {http://hdl.handle.net/10481/69001},
abstract = {MiRNAs play a relevant role in PC (prostate cancer) by the regulation in the expression of
several pathways’ AR (androgen receptor), cellular cycle, apoptosis, MET (mesenchymal epithelium
transition), or metastasis. Here, we report the role of several miRNAs’ expression patterns, such
as miR-miR-93-5p, miR-23c, miR-210-3p, miR-221-3p, miR-592, miR-141, miR-375, and miR-130b,
with relevance in processes like cell proliferation and MET. Using Trizol® extraction protocol and
TaqMan™ specific probes for amplification, we performed miRNAs’ analysis of 159 PC fresh tissues
and 60 plasmas from peripheral blood samples. We had clinical data from all samples including PSA,
Gleason, TNM, and D’Amico risk. Moreover, a bioinformatic analysis in TCGA (The Cancer Genome
Atlas) was included to analyze the effect of the most relevant miRNAs according to aggressiveness
in an extensive cohort (n = 531). We found that miR-210-3p, miR-23c, miR-592, and miR-93-5p are
the most suitable biomarkers for PC aggressiveness and diagnosis, respectively. In fact, according
with our results, miR93-5p seems the most promising non-invasive biomarker for PC. To sum up,
miR-210-3p, miR-23c, miR-592, and miR93-5p miRNAs are suggested to be potential biomarkers
for PC risk stratification that could be included in non-invasive strategies such as liquid biopsy in
precision medicine for PC management.},
organization = {Regional Ministry of Health and Families of the
Andalusian Government (ref: PI-0319-2018)},
organization = {FIBAO (Andalusian Public Foundation
for Biomedical Research in Eastern Andalusia, “Alejandro Otero”)},
publisher = {MDPI},
keywords = {Aggressiveness},
keywords = {Biomarkers},
keywords = {Bioinformatics},
keywords = {Precision medicine},
keywords = {Prostate cancer},
title = {Identification of MiRNAs as Viable Aggressiveness Biomarkers for Prostate Cancer},
doi = {10.3390/biomedicines9060646},
author = {Martínez González, Luis Javier and Sánchez Conde, Victor and González Cabezuelo, Jose María and Antúnez Rodríguez, Alba and Andrés-León, Eduardo and Robles Fernández, Inmaculada and Lorente Acosta, José Antonio and Vázquez Alonso, Fernando and Álvarez Cubero, María Jesús},
}