@misc{10481/68610,
year = {2021},
url = {http://hdl.handle.net/10481/68610},
abstract = {BACKGROUND: During early life, dynamic gut colonization and brain development
co-occur with potential cross-talk mechanisms affecting behaviour. METHODS: We used 16S rRNA
gene sequencing to examine the associations between gut microbiota and neurodevelopmental
outcomes assessed by the Bayley Scales of Infant Development III in 71 full-term healthy infants at
18 months of age. We hypothesized that children would differ in gut microbial diversity, enterotypes
obtained by Dirichlet multinomial mixture analysis and specific taxa based on their behavioural
characteristics. RESULTS: In children dichotomized by behavioural trait performance in above- and
below-median groups, weighted Unifrac b-diversity exhibited significant differences in fine motor
(FM) activity. Dirichlet multinomial mixture modelling identified two enterotypes strongly associated
with FM outcomes. When controlling for maternal pre-gestational BMI and breastfeeding for up to
3 months, the examination of signature taxa in FM groups showed that Turicibacter and Parabacteroides
were highly abundant in the below-median FM group, while Collinsella, Coprococcus, Enterococcus,
Fusobacterium, Holdemanella, Propionibacterium, Roseburia, Veillonella, an unassigned genus within
Veillonellaceae and, interestingly, probiotic Bifidobacterium and Lactobacillus were more abundant in the
above-median FM group. CONCLUSIONS: Our results suggest an association between enterotypes
and specific genera with FM activity and may represent an opportunity for probiotic interventions
relevant to treatment for motor disorders.},
organization = {Spanish Ministry of Innovation and Science},
organization = {Junta de Andalucía: Excellence Projects (P06-CTS-02341)},
organization = {Spanish Ministry of Economy and Competitiveness
(BFU2012-40254-C03-02) and partially funded by the European Commission MyNewGut FP7 EU Project (Grant agreement n◦ 613979)},
organization = {MyNewGut FP7 EU Project (Grant agreement n◦ 613979)},
organization = {DynaHEALTH EU
Project HORIZON 2020 (Grant agreement n◦
: 633595-2)},
organization = {Marie Curie post-doctoral fellowship (FP7,
no. 329812, NutriOmics)},
organization = {Spanish Ministry
of Education, Culture and Sports (FPU16/04587)},
publisher = {MDPI},
keywords = {Microbiota},
keywords = {Neurodevelopment},
keywords = {Gut–brain axis},
keywords = {Fine motricity},
keywords = {Probiotics},
title = {Infant Gut Microbiota Associated with Fine Motor Skills},
doi = {10.3390/nu13051673},
author = {Acuña Morales, Inmaculada and Torres Espinola, Francisco Jose and López Moreno, Ana and Aguilera Gómez, Margarita and Suárez García, Antonio Francisco and Campoy Folgoso, Cristina},
}