@misc{10481/68609,
year = {2021},
url = {http://hdl.handle.net/10481/68609},
abstract = {Sex is a common baseline factor collected in studies that has the potential to be a prognostic
factor (PF) in several clinical areas. In recent years, research on sex as a PF has increased; however,
this influx of new studies frequently shows conflicting results across the same treatment or disease
state. Thus, systematic reviews (SRs) addressing sex as a PF may help us to better understand
diseases and further personalize healthcare. We wrote this article to offer insights into the challenges
we encountered when conducting SRs on sex as a PF and suggestions on how to overcome these
obstacles, regardless of the clinical domain. When carrying out a PF SR with sex as the index factor,
it is important to keep in mind the modifications that must be made in various SR stages, such as
modifying the PF section of CHARMS-PF, adjusting certain sections of QUIPS and extracting data on
the sex and gender terms used throughout the studies. In this paper, we provide an overview of the
lessons learned from carrying out our reviews on sex as a PF in different disciplines and now call on
researchers, funding agencies and journals to realize the importance of studying sex as a PF.},
organization = {Instituto de Salud Carlos III (Plan Estatal de I
+ D + i 2013–2016)},
organization = {European Development Regional Fund. “A way to achieve
Europe” (ERDF) grant number PIE16/00050},
publisher = {MDPI},
keywords = {Sex},
keywords = {Gender},
keywords = {Prognosis},
keywords = {prognostic factor},
keywords = {Systematic review},
keywords = {Methods},
title = {Sex as a Prognostic Factor in Systematic Reviews: Challenges and Lessons Learned},
doi = {10.3390/jpm11060441},
author = {Stallings, Elena and García Martín, Miguel Ángel},
}