@misc{10481/68438,
year = {2021},
url = {http://hdl.handle.net/10481/68438},
abstract = {MamC-mediated biomimetic magnetic nanoparticles (BMNPs) have emerged as one of
the most promising nanomaterials due to their magnetic features (superparamagnetic character and
large magnetic moment per particle), their novel surface properties determined by MamC, their
biocompatibility and their ability as magnetic hyperthermia agents. However, the current clinical
application of magnetic hyperthermia is limited due to the fact that, in order to be able to reach
an effective temperature at the target site, relatively high nanoparticle concentration, as well as
high magnetic field strength and/or AC frequency are needed. In the present study, the potential
of BMNPs to increase the temperature upon irradiation of a laser beam in the near infrared, at
a wavelength at which tissues become partially transparent, is explored. Moreover, our results
also demonstrate the synergy between photothermia and chemotherapy in terms of drug release
and cytotoxicity, by using BMNPs functionalized with doxorubicin, and the effectiveness of this
combination therapy against tumor cells in in vitro experiments. Therefore, the findings of the
present study open the possibility of a novel, alternative approach to fight localized tumors.},
organization = {Ministerio de Economía y Competitividad (CGL2016-
76723 and PID2019-109294RB-100 projects)},
organization = {Ramón y Cajal program (RYC-2014-16901)},
organization = {Junta de
Andalucía. Programa Operativo FEDER 2014–2020. (A1-FQM-341-UGR18, C-FQM-497-UGR18, A-BIO376-UGR18).},
organization = {Andalusian regional government (CTS-236)},
organization = {Formación de Doctores 2018 grant (ref. PRE2018-085440) from the Ministerio de
Ciencia, Innovación y Universidades (Spain)},
organization = {Unidad Cientifica de Excelencia UCE-PP2016-05},
organization = {Instituto de Biotecnología of the University of
Granada},
publisher = {MDPI},
keywords = {Biomimetic magnetic nanoparticles},
keywords = {Combined tumor therapy},
keywords = {Doxorubicin},
keywords = {HepG2 cancer cell line},
keywords = {MamC},
keywords = {Magnetite nanoparticles},
keywords = {Photothermia},
title = {Synergistic Photothermal-Chemotherapy Based on the Use of Biomimetic Magnetic Nanoparticles},
doi = {10.3390/pharmaceutics13050625},
author = {Jabalera Ruz, Ylenia María and Sola Leyva, Alberto and Carrasco Jiménez, María Paz and Iglesias Salto, Guillermo Ramón and Jiménez López, Concepción},
}