@misc{10481/68304,
year = {2020},
url = {http://hdl.handle.net/10481/68304},
abstract = {Background Dementia is associated with a high burden of dependency and disability. Physical frailty (hereafter
referred to as frailty) is a multisystem dysregulation that has been identified as a risk factor for dementia. The aim of
this study was to examine the association of frailty and its individual components with all-cause dementia incidence
in a cohort of UK adults.
Methods Participants in UK Biobank with data available for dementia incidence and without any form of dementia at
baseline were included in this prospective study. Frailty was defined using a modified version of the frailty phenotype
based on five individual components (weight loss, tiredness, physical activity, gait speed, and grip strength), with
participants classified as pre-frail if they fulfilled one or two criteria or frail if they fulfilled three or more. Associations
between frailty and dementia incidence were investigated using Cox proportional hazard models adjusted for
sociodemographic factors, lifestyle factors, and morbidity count. The population attributable fraction was also
estimated.
Findings Of 502535 participants in UK Biobank, 143 215 met the inclusion criteria and were included in our analyses.
68 500 (47·8%) of the participants were pre-frail and 5565 (3·9%) were frail. During a median follow-up period of
5·4 years, 726 individuals developed dementia. Compared with non-frail individuals, the risk of dementia incidence
was increased for individuals with pre-frailty (hazard ratio 1·21 [95% CI 1·04–1·42]) and frailty (1·98 [1·47–2·67]) in
the fully adjusted model. Of the five components used to define frailty, weight loss (1·31 [1·09–1·58]),
tiredness (1·48 [1·18–1·86]), low grip strength (1·38 [1·17–1·63]), and slow gait speed (1·55 [1·22–1·96]) were
independently associated with incident dementia. Based on population attributable fraction analyses, in the study
sample, pre-frailty and frailty accounted for 9·9% and 8·6% of dementia cases, respectively.
Interpretation Individuals with pre-frailty and frailty were at a higher risk of dementia incidence even after adjusting
for a wide range of confounding factors. Early detection and interventions for frailty could translate into prevention or
delayed onset of dementia.},
publisher = {ELSEVIER},
title = {Associations between physical frailty and dementia incidence: a prospective study from UK Biobank},
doi = {10.1016/S2666-7568(20)30007-6},
author = {Petermann Rocha, Fanny and Esteban Cornejo, Irene},
}