@misc{10481/68113,
year = {2021},
url = {http://hdl.handle.net/10481/68113},
abstract = {For decades, several attempts have been made to obtain a mimetic model for
the study of metastasis, the reason of most of deaths caused by cancer, in
order to solve the unknown phenomena surrounding this disease. To better
understand this cellular dissemination process, more realistic models are
needed that are capable of faithfully recreating the entire and essential tumor
microenvironment (TME). Thus, new tools known as tumor-on-a-chip and
metastasis-on-a-chip have been recently proposed. These tools incorporate
microfluidic systems and small culture chambers where TME can be faithfully
modeled thanks to 3D bioprinting. In this work, a literature review has been
developed about the different phases of metastasis, the remaining unknowns
and the use of new models to study this disease. The aim is to provide a
global vision of the current panorama and the great potential that these
systems have for in vitro translational research on the molecular basis of the
pathology. In addition, these models will allow progress toward a personalized medicine, generating chips from patient samples that mimic the original
tumor and the metastatic process to perform a precise pharmacological
screening by establishing the most appropriate treatment protocol.},
organization = {Ministerio de Educacion y Formacion Profesional 

FPU19/02138
BOE-B-2019-44783},
organization = {Ph.D. program of Biomedicine of the University of Granada},
organization = {Consejeria de Economia, Conocimiento, Empresas y Universidad, Junta de Andalucia (FEDER Funds) 

P18-FR-2470
B-CTS-230-UGR18
SOMM17/6109/UGR},
organization = {Instituto de Salud Carlos III (FEDER Funds) 

PIE16-00045
DTS19/00145},
organization = {Junta de Andalucia

PIN-0224-2019},
organization = {Chair "Doctors Galera-Requena in cancer stem cell research" 

CMC-CTS963},
publisher = {WILEY-V C H VERLAG GMBH},
title = {Evolution of Metastasis Study Models toward MetastasisOn-A-Chip: The Ultimate Model?},
doi = {10.1002/smll.202006009},
author = {Ruiz Espigares, Jesús and Jiménez, Gema and Marchal Corrales, Juan Antonio and Nieto, Daniel and Moroni, Lorenzo},
}