@misc{10481/68051,
year = {2021},
month = {3},
url = {http://hdl.handle.net/10481/68051},
abstract = {Carotenoids are pigments contained mainly in fruit and vegetables (F&V) that have beneficial effects on cardiometabolic health. Due to their lipophilic nature, co-ingestion of fat appears to increase their bioavailability via facilitating transfer to the aqueous micellar phase during digestion. However, the extent to which high fat intake may contribute to increased carotenoid plasma concentrations is still unclear. The objective was to examine the degree to which the consumption of different amounts of both carotenoid-rich foods and fats is associated with plasma carotenoid concentrations within a Mediterranean lifestyle context (subsample from the PREDIMED-Plus study baseline) where consumption of F&V and fat is high. The study population was categorized into four groups according to their self-reported consumption of F&V and fat. Carotenoids were extracted from plasma samples and analyzed by HPLC-UV-VIS-QqQ-MS/MS. Carotenoid systemic concentrations were greater in high consumers of F&V than in low consumers of these foods (+3.04 mu mol/L (95% CI: 0.90, 5.17), p-value = 0.005), but circulating concentrations seemed to decrease when total fat intake was very high (-2.69 mu mol/L (-5.54; 0.16), p-value = 0.064). High consumption of F&V is associated with greater systemic levels of total carotenoids, in particular when fat intake is low-to-moderate rather than very high.},
organization = {Consejo Interinstitucional de Ciencia y Tecnologia (CICYT)

European Commission

AGL2016-75329-R},
organization = {CIBEROBN from the Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovacion y Universidades, (AEI/FEDER)},
organization = {Generalitat de Catalunya

2017SGR196},
organization = {CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn)},
organization = {Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund 

PI13/00673
PI13/00492
PI13/00272
PI13/01123
PI13/00462
PI13/00233
PI13/02184
PI13/00728
PI13/01090
PI13/01056
PI14/01722
PI14/00636
PI14/00618
PI14/00696
PI14/01206
PI14/01919
PI14/00853
PI14/01374
PI14/00972
PI14/01471
PI16/00473},
organization = {Especial Action Project entitled Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant},
organization = {European Research Council (ERC)

European Commission

340918},
organization = {Recercaixa grant 

2013ACUP00194},
organization = {Junta de Andalucia

PI0458/2013
PS0358/2016
PI0137/2018},
organization = {Generalitat Valenciana

European Commission

PROMETEO/2017/017},
organization = {SEMERGEN grant},
organization = {Fundacio la Marato de TV3 

PI044003},
organization = {Generalitat de Catalunya

2017 SGR 1717},
organization = {CICYT grant by the Ministerio de Ciencia, Innovacion y Universidades 

AGL2016-75329-R},
organization = {European Commission

CB06/03},
organization = {"FOLIUM" program within the FUTURMed project entitled Talent for the medicine within the future from the Fundacio Institut d'Investigacio Sanitaria Illes Balears},
organization = {ICREA under the ICREA Academia programme},
organization = {Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)

2019/11324-8
2013/07914-8},
organization = {the Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund 

PI16/00501
PI16/00533
PI16/00381
PI16/00366
PI16/01522
PI16/01120
PI17/00764
PI17/01183
PI17/00855
PI17/01347
PI17/00525
PI17/01827
PI17/00532
PI17/00215
PI17/01441
PI17/00508
PI17/01732
PI17/00926
PI19/00781
PI14/00728
PI16/00662
PI16/01873
PI16/01094
 

FPU17/00513
 

CD17/00122},
publisher = {MDPI},
keywords = {Bioactive compounds},
keywords = {Phytochemicals},
keywords = {Dietary fats},
keywords = {Mediterranean diet},
keywords = {PREDIMED-Plus study},
keywords = {Plasma carotenoids},
keywords = {Matrix effect absorption},
keywords = {Liquid chromatography},
keywords = {Mass spectrometry},
title = {High Fruit and Vegetable Consumption and Moderate Fat Intake Are Associated with Higher Carotenoid Concentration in Human Plasma},
doi = {10.3390/antiox10030473},
author = {Marhuenda-Muñoz, María and Bueno Cavanillas, Aurora},
}