@misc{10481/68037,
year = {2020},
month = {12},
url = {http://hdl.handle.net/10481/68037},
abstract = {Microbiota has a role in the host blood pressure (BP) regulation. The immunosuppressive drug mofetil mycophenolate
(MMF) ameliorates hypertension. The present study analyzes whether MMF improves dysbiosis in a
genetic model of hypertension. Twenty weeks old male spontaneously hypertensive rats (SHR) and Wistar Kyoto
rats (WKY) were randomly divided into three groups: untreated WKY, untreated SHR, and SHR treated with MMF
for 5 weeks. MMF treatment restored gut bacteria from the phyla Firmicutes and Bacteroidetes, and acetate- and
lactate-producing bacteria to levels similar to those found in WKY, increasing butyrate-producing bacteria. MMF
increased the percentage of anaerobic bacteria in the gut. The improvement of gut dysbiosis was associated with
an enhanced colonic integrity and a decreased sympathetic drive in the gut. MMF inhibited neuroinflammation
in the paraventricular nuclei in the hypothalamus. MMF increased the lower regulatory T cells proportion in
mesenteric lymph nodes and Th17 and Th1 infiltration in aorta, improved aortic endothelial function and
reduced systolic BP. This study demonstrates for the first time that MMF reduces gut dysbiosis in SHR. This effect
could be related to its capability to improve gut integrity due to reduced sympathetic drive in the gut associated
to the reduced brain neuroinflammation.},
organization = {Comision Interministerial de Ciencia y Tecnologia, Ministerio de Economia y competitividad 

SAF201784894R},
organization = {Junta de Andalucia

CTS-164},
organization = {European Commission},
organization = {Spanish Government},
organization = {Instituto de Salud Carlos III (CIBERCV) , Spain},
organization = {European Union (Fondo Europeo de Desarrollo Regional, FEDER, "FEDER una manera de hacer Europa")},
publisher = {Elsevier},
keywords = {Mycophenolate},
keywords = {Gut dysbiosis},
keywords = {Hypertension},
keywords = {Oxidative stress},
keywords = {Inflammation},
keywords = {SHR},
title = {Mycophenolate mediated remodeling of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rats},
doi = {10.1016/j.biopha.2020.111189},
author = {Robles Vera, Iñaki and de la Visitación, Néstor and Sánchez, Manuel and Gómez Guzmán, Manuel and Jiménez Moleón, Rosario and Romero, Miguel and Duarte Pérez, Juan Manuel},
}