@misc{10481/67870,
year = {2021},
month = {1},
url = {http://hdl.handle.net/10481/67870},
abstract = {Luminescent lanthanide-containing biocompatible nanosystems represent promising candidates
as nanoplatforms for bioimaging applications. Herein, citrate-functionalized calcium-doped
terbium phosphate hydrate nanophosphors of the rhabdophane type were prepared at different
synthesis times and different Ca2+/Tb3+ ratios by a bioinspired crystallization method consisting of
thermal decomplexing of Ca2+/Tb3+/citrate/phosphate/carbonate solutions. Nanoparticles were
characterized by XRD, TEM, SEM, HR-TEM, FTIR, Raman, Thermogravimetry, inductively coupled
plasma spectroscopy, thermoanalysis, dynamic light scattering, electrophoretic mobility, and fluorescence
spectroscopy. They displayed ill-defined isometric morphologies with sizes  50 nm, hydration
number n ~ 0.9, tailored Ca2+ content (0.42–8.11 wt%), and long luminescent lifetimes (800–2600
 s). Their relative luminescence intensities in solid state are neither affected by Ca2+, citrate content,
nor by maturation time for Ca2+ doping concentration in solution below 0.07 M Ca2+. Only at this
doping concentration does the maturation time strongly affect this property, decreasing it. In aqueous
suspensions, neither pH nor ionic strength nor temperature affect their luminescence properties.
All the nanoparticles displayed high cytocompatibility on two human carcinoma cell lines and cell
viability correlated positively with the amount of doping Ca2+. Thus, these nanocrystals represent
promising new luminescent nanoprobes for potential biomedical applications and, if coupled with
targeting and therapeutic moieties, they could be effective tools for theranostics.},
organization = {Spanish Agencia Estatal de Investigación of the Ministerio de Ciencia, Innovación y Universidades (MICIU)},
organization = {European Commission

PGC2018102047-B-I00},
organization = {Spanish Ministerio de Economía y Competitividad 

CTQ2017-88079-P},
publisher = {Mdpi},
keywords = {Terbiumphosphates},
keywords = {Calciumdoped},
keywords = {Citrate},
keywords = {Nanoparticles},
keywords = {Luminescence},
keywords = {Cytocompatibility},
title = {Crystallization, Luminescence and Cytocompatibility of Hexagonal Calcium Doped Terbium Phosphate Hydrate Nanoparticles},
author = {Gómez Morales, Jaime and Fernández Penas, Raquel and Romero Castillo, Ismael and Verdugo Escamilla, Cristóbal and Choquesillo Lazarte, Duane and Fernández Sánchez, Jorge Fernando},
}