@misc{10481/67851,
year = {2021},
month = {1},
url = {http://hdl.handle.net/10481/67851},
abstract = {The brain renin–angiotensin system (RAS) has been recently involved in the homeostatic
regulation of energy. Our goal was to analyse the influence of a diet rich in saturated fatty acids
(butter) against one enriched in monounsaturated fatty acids (olive oil) on hypothalamic RAS,
and their relationship with the metabolism of fatty acids. Increases in body weight and visceral fat,
together with an increase in aminopeptidase A expression and reductions in AngII and AngIV were
observed in the hypothalamus of animals fed with the butter diet. In this group, a marked reduction
in the expression of genes related to lipid metabolism (LPL, CD36, and CPT-1) was observed in liver
and muscle. No changes were found in terms of body weight, total visceral fat and the expression
of hepatic genes related to fatty acid metabolism in the olive oil diet. The expressions of LPL and
CD36 were reduced in the muscles, although the decrease was lower than in the butter diet. At the
same time, the fasting levels of leptin were reduced, no changes were observed in the hypothalamic
expression of aminopeptidase A and decreases were noted in the levels of AngII, AngIV and AngIII.
These results support that the type of dietary fat is able to modify the hypothalamic profile of RAS
and the body energy balance, related to changes in lipid metabolism.},
organization = {University of Jaen 

PP2009/13/03},
publisher = {Mdpi},
keywords = {Virgin olive oil},
keywords = {Brain renin–angiotensin system;},
keywords = {Fatty acid metabolism},
keywords = {Energy balance},
title = {Hypothalamic Renin–Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet},
doi = {10.3390/nu13020480},
author = {Segarra, Ana Belén and Domínguez Vías, German},
}