@misc{10481/67801,
year = {2021},
month = {3},
url = {http://hdl.handle.net/10481/67801},
abstract = {Extracellular matrix (ECM) remodeling plays important roles in both white adipose tissue
(WAT) and the skeletal muscle (SM) metabolism. Excessive adipocyte hypertrophy causes fibrosis,
inflammation, and metabolic dysfunction in adipose tissue, as well as impaired adipogenesis.
Similarly, disturbed ECM remodeling in SM has metabolic consequences such as decreased insulin
sensitivity. Most of described ECM molecular alterations have been associated with DNA sequence
variation, alterations in gene expression patterns, and epigenetic modifications. Among others, the
most important epigenetic mechanism by which cells are able to modulate their gene expression
is DNA methylation. Epigenome-Wide Association Studies (EWAS) have become a powerful approach
to identify DNA methylation variation associated with biological traits in humans. Likewise,
Genome-Wide Association Studies (GWAS) and gene expression microarrays have allowed the study
of whole-genome genetics and transcriptomics patterns in obesity and metabolic diseases. The aim
of this review is to explore the molecular basis of ECM inWAT and SM remodeling in obesity and
the consequences of metabolic complications. For that purpose, we reviewed scientific literature
including all omics approaches reporting genetic, epigenetic, and transcriptomic (GWAS, EWAS, and
RNA-seq or cDNA arrays) ECM-related alterations in WAT and SM as associated with metabolic
dysfunction and obesity.},
organization = {Doctorate fellowship Formacion del Profesorado Universitario 

FPU 16/03653},
organization = {Doctorate contract i-PFIS: Doctorados IIS-empresa en ciencias y tecnologias de la salud 

IFI17/00048},
organization = {"Ramon-Areces Foundation", Spain},
organization = {Junta de Andalucía},
publisher = {Mdpi},
keywords = {Obesity},
keywords = {Adipose tissues},
keywords = {Extracellular-matrix},
keywords = {Skeletal muscle},
keywords = {Genetics},
keywords = {Epigenetic},
keywords = {Transcriptomic},
title = {Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic Dysfunction},
doi = {10.3390/ijms22052756},
author = {Anguita Ruiz, Augusto and Bustos Aibar, Mireia and Plaza Díaz, Julio and Mendez Gutierrez, Andrea and Alcalá Fernández, Jesús and Aguilera García, Concepción María and Ruiz Ojeda, Francisco Javier},
}