@misc{10481/67688,
year = {2021},
month = {2},
url = {http://hdl.handle.net/10481/67688},
abstract = {Our aim was to assess the combination of olive tree-related extracts with the most favorable
profile of in vitro bioactive properties. We tested the antioxidant (increment of low-density
lipoprotein resistance against oxidation), vasoactive (promotion of nitric oxide release and decrease
of endothelin-1 production in human umbilical vein endothelial cells), anti-inflammatory (decrease
of the endothelial production of vascular cell adhesion molecule-1), and antithrombotic (reduction of
the endothelial release of plasminogen activator inhibitor-1) capacities of six phenolic extracts and
three triterpenic acid solutions (Ps and Ts, respectively). We tested extracts alone and in combination,
at nutritional (Ps: 0.05–0.5  mol/L; Ts: 0.001–0.1  mol/L) and nutraceutical doses (Ps: 1–10  mol/L;
Ts: 0.25–10  mol/L). The combination of Ps rich in 3,4-dihydroxyphenylglycol (76%, P2), hydroxytyrosol
(95%, P3), and oleuropein (70%, P4) (final nutritional concentration: 0.15  mol/L; final
nutraceutical concentration: 3  mol/L) was the best in order to prepare functional products and
nutraceuticals with cardioprotective properties, despite the fact that the isolated extract with the
greatest in vitro properties was P5 (75% oleocanthal), suggesting a potential synergistic effect among
different olive components.},
organization = {Spanish Ministry of Economy, Industry and Competitiveness, through the FEDER INNTERCONECTA Program of the Center for Industrial Technological Development (CDTI)},
organization = {Junta de Andalucía

ITC-20151142
EXP 00083147},
organization = {Instituto de Salud Carlos III

European Commission

CB06/03/0028
CD17/00122
CES12/025
JR17/00022},
organization = {European Commission},
publisher = {Mdpi},
keywords = {Olive tree},
keywords = {Phenolic compounds},
keywords = {Triterpenes},
keywords = {Bioactivity},
keywords = {Functional olive oil},
keywords = {3,4-dihydroxyphenylglycol},
keywords = {Hydroxytyrosol},
keywords = {Oleuropein},
keywords = {Oleocanthal},
title = {From Green Technology to Functional Olive Oils: Assessing the Best Combination of Olive Tree-Related Extracts with Complementary Bioactivities},
doi = {10.3390/antiox10020202},
author = {Hernáez, Álvaro and Espejo Calvo, Juan Antonio and Carrasco Pancorbo, Alegría and Mesa García, María Dolores},
}