@misc{10481/67345,
year = {2021},
month = {2},
url = {http://hdl.handle.net/10481/67345},
abstract = {In this manuscript, we report the development of a versatile,
robust, and stable targeting nanocarrier for active delivery. This
nanocarrier is based on bifunctionalized polymeric nanoparticles
conjugated to a monoclonal antibody that allows for active targeting
of either (i) a fluorophore for tracking or (ii) a drug for monitoring
specific cell responses. This nanodevice can efficiently discriminate
between cells in coculture based on the expression
levels of cell surface receptors. As a proof of concept, we have
demonstrated efficient delivery using a broadly established cell
surface receptor as the target, the epidermal growth factor receptor
(EGFR), which is overexpressed in several types of cancers.
Additionally, a second validation of this nanodevice was successfully
carried out using another cell surface receptor as the target,
the cluster of differentiation 147 (CD147). Our results suggest that
this versatile nanocarrier can be expanded to other cell receptors
and bioactive cargoes, offering remarkable discrimination
efficiency between cells with different expression levels of a
specific marker. This work supports the ability of nanoplatforms to
boost and improve the progress towards personalized medicine.},
organization = {Health Institute Carlos III (ISCIII) 

DTS18/00121},
organization = {Junta de Andalucia-FEDER, Ministry of Economy, Knowledge, Companies and University (University of Granada) 

B-FQM-475-UGR18
PT18-TP-1490
AT17_6096- OTRI},
organization = {Spanish State Research Agency 

RED2018-102469-T},
organization = {Fundación Benéfica Anticáncer San Francisco Javier y Santa Cándida},
organization = {Spanish Ministry of Economy and Competitiveness 

PTQ-16- 08597},
organization = {Spanish Government

FPU 16/02061},
publisher = {Royal Society Chemistry},
title = {An effective polymeric nanocarrier that allows for active targeting and selective drug delivery in cell coculture systems},
doi = {10.1039/d0nr07145e},
author = {Cano Cortes, María Victoria and Altea-Manzano, Patricia and Laz Ruiz, José Antonio and Unciti Broceta, Juan Diego and López Delgado, Francisco Javier and Espejo Román, José Manuel and Díaz Mochón, Juan José and Sánchez Martín, Rosario María},
}