@misc{10481/67258,
year = {2021},
month = {2},
url = {http://hdl.handle.net/10481/67258},
abstract = {Alcohol consumption is causally linked to several cancers but the evidence for stomach
cancer is inconclusive. In our study, the association between long-term alcohol
intake and risk of stomach cancer and its subtypes was evaluated. We performed a
pooled analysis of data collected at baseline from 491 714 participants in the
European Prospective Investigation into Cancer and Nutrition and the Melbourne
Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs)
were estimated for incident stomach cancer in relation to lifetime alcohol intake and
group-based life course intake trajectories, adjusted for potential confounders including
Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia)
were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants
with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol
intake was not associated with overall stomach cancer risk, we observed a weak positive
association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d
increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to
4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00)
was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI:
0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These
associations did not differ appreciably by smoking or H pylori infection status. Limiting
alcohol use during lifetime, particularly avoiding heavy use during early adulthood,
might help prevent noncardia stomach cancer. Heterogeneous associations observed
for cardia and noncardia cancers may indicate etiologic differences.},
organization = {National Health and Medical Research Council of Australia

1074383
209057
396414
GNT1163120},
organization = {Canadian Institutes of Health Research (CIHR)

Cancer Council Victoria},
organization = {Cancer Research UK

C570/A16491
C8221/A19170
C864/A14136},
organization = {Catalan Institute of Oncology - ICO (Spain)},
organization = {Danish Cancer Society},
organization = {Deutsche Krebshilfe},
organization = {Deutsches Krebsforschungszentrum (Germany)},
organization = {Dutch Ministry of Public Health, Welfare and Sports},
organization = {European Commission

European Commission Joint Research Centre},
organization = {Foundation for Alcohol Research and Education (Australia)},
organization = {French Ministry of Health 

GR-IARC-2003-09-12-01},
organization = {Health Research Fund (FIS) -Instituto de Salud Carlos III (ISCIII)},
organization = {Junta de Andalucía},
organization = {Regional Government of Asturias},
organization = {Basque Government},
organization = {Regional Government of Murcia},
organization = {Regional Government of Navarra},
organization = {Hellenic Health Foundation (Greece)},
organization = {Hellenic Ministry of Health and Social Solidarity (Greece)},
organization = {Institut National de la Sante et de la Recherche Medicale (Inserm)},
organization = {Consiglio Nazionale delle Ricerche (CNR)},
organization = {Associazione Italiana per la Ricerca sul Cancro (AIRC)},
organization = {Ligue Contre le Cancer (France)},
organization = {LK Research Funds},
organization = {Dutch Prevention Funds},
organization = {Netherlands Organization for Scientific Research (NWO)},
organization = {UK Research & Innovation (UKRI)

Medical Research Council UK (MRC)

MC-UU_12015/1
MR/M012190/1
MR/N003284/},
organization = {Mutuelle Generale de l'Education Nationale},
organization = {National Institute for Public Health and the Environment (RIVM) (the Netherlands)},
organization = {Netherlands Cancer Registry},
organization = {Stavros Niarchos Foundation (Greece)},
organization = {Stroke Association (UK)},
organization = {British Heart Foundation},
organization = {Department of Health (UK)},
organization = {Food Standards Agency (UK)},
organization = {Wellcome Trust},
organization = {Swedish Cancer Society},
organization = {Swedish Scientific Council (Sweden)},
organization = {Regional Government of Skane (Sweden)},
organization = {Federal Ministry of Education & Research (BMBF)},
organization = {VicHealth (Australia)},
organization = {World Cancer Research Fund and Statistics Netherlands (the Netherlands)},
organization = {Institut Gustave Roussy},
publisher = {Wiley},
keywords = {Cardia cancer},
keywords = {EPIC},
keywords = {Lifetime alcohol intake},
keywords = {MCCS},
keywords = {Noncardia cancer},
keywords = {Stomach cancer},
title = {Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies},
doi = {10.1002/ijc.33504},
author = {Jayasekara, Harindra and Sánchez Pérez, María José},
}