@misc{10481/67105,
year = {2020},
month = {12},
url = {http://hdl.handle.net/10481/67105},
abstract = {The  objective  was  to  state  zinc  contribution  in  the  effectiveness  of  novel  zinc-doped  dentin  cements  to  achieve  dentin  remineralization,  throughout  a  literature  or  narrative  exploratory review. Literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. Both zinc-doping silicate and hydroxyapatite-based cements provoked an increase of both bioactivity and intrafibrillar   mineralization   of   dentin.   Zinc-doped   hydroxyapatite-based   cements   (oxipatite)  also  induced  an  increase  in  values  of  dentin  nano-hardness,  Young’s  modulus  and  dentin  resistance  to  deformation.  From  Raman  analyses,  it  was  stated  higher intensity of phosphate peaks and crystallinity as markers of dentin calcification, in  the  presence  of  zinc.  Zinc-based  salt  formations  produced  low  microleakage  and  permeability values with hermetically sealed tubules at radicular dentin. Dentin treated with  oxipatite  attained  preferred  crystal  grain  orientation  with  polycrystalline  lattices.  Thereby, oxipatite mechanically reinforced dentin structure, by remineralization. Dentin treated  with  oxipatite  produced  immature  crystallites  formations,  accounting  for  high  hydroxyapatite solubility, instability and enhanced remineralizing activity.},
organization = {This  work  was  supported  by  the  Ministry  of  Economy  and  Competitiveness  and  European Regional Development Fund [MAT2017-85999PMINECO/AEI/FEDER/UE].},
keywords = {Zinc},
keywords = {Cement},
keywords = {Dentin},
keywords = {Remineralization},
keywords = {Bioactivity},
title = {Zn-doping of silicate and hydroxyapatite-based cements: dentin mechanobiology and bioactivity},
doi = {https://doi.org/10.1016/j.jmbbm.2020.104232},
author = {Toledano Pérez, Manuel and Osorio Ruiz, Raquel and Vallecillo-Rivas, Marta and Osorio Ruiz, María Estrella and Lynch, Christopher D. and Aguilera, Fátima S. and Toledano, Raquel and Sauro, Salvatore},
}