@misc{10481/66971, year = {2021}, month = {1}, url = {http://hdl.handle.net/10481/66971}, abstract = {Carbapenemase-producing Enterobacterales (CPE) are significant contributors to the global public health threat of antimicrobial resistance. OXA-48-like enzymes and their variants are unique carbapenemases with low or null hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins. CPEs have been classified by the WHO as high-priority pathogens given their association with morbidity and mortality and the scarce number of effective antibiotic treatments. In Spain, the frequency of OXA-48 CPE outbreaks is higher than in other European countries, representing the major resistance mechanism of CPEs. Horizontal transfer of plasmids and poor effective antibiotic treatment are additional threats to the correct prevention and control of these hospital outbreaks. One of the most important risk factors is antibiotic pressure, specifically carbapenem overuse. We explored the use of these antibiotics in Spain and analyzed the frequency, characteristics and prevention of CPE outbreaks. Future antibiotic stewardship programs along with specific preventive measures in hospitalized patients must be reinforced and updated in Spain.}, organization = {Chair of Teaching and Research in Family Medicine SEMERGEN-UGR}, publisher = {Mdpi}, keywords = {OXA-48}, keywords = {Carbapenem}, keywords = {Carbapenemases}, keywords = {Spain}, keywords = {Outbreak}, keywords = {Multiresistant}, keywords = {Enterobacteria}, keywords = {Antibiotic stewardship}, title = {OXA-48 Carbapenemase-Producing Enterobacterales in Spanish Hospitals: An Updated Comprehensive Review on a Rising Antimicrobial Resistance}, doi = {10.3390/antibiotics10010089}, author = {Rivera Izquierdo, Mario and Láinez Ramos-Bossini, Antonio Jesús and Rivera Izquierdo, Carlos and López Gómez, Jairo and Fernández Martínez, Nicolás Francisco and Redruello Guerrero, Pablo and Martín de los Reyes, Luis Miguel and Martínez Ruiz, Virginia Ana and Moreno Roldán, Elena and Jiménez Mejías, Eladio}, }