@misc{10481/66970,
year = {2021},
month = {1},
url = {http://hdl.handle.net/10481/66970},
abstract = {Background: Selenium (Se) is a trace element with a narrow safety margin.
Objectives: To evaluate the cross-sectional and longitudinal dose-response association between Se exposure and
measures of impaired physical function and disability in older adults.
Design: NHANES 2011–2014 cross-sectional (US, n = 1733, age ≥60 years) and Seniors-ENRICA-2 2017–2019
cross-sectional and longitudinal (Spain, n = 2548 and 1741, respectively, age ≥65 years) data were analyzed.
Whole blood and serum Se levels were measured using inductively coupled plasma-mass spectrometry. Lowerextremity
performance was assessed with the Short Physical Performance Battery, and muscle weakness with
a dynamometer. Incident mobility and agility limitations, and disability in instrumental activities of daily living
(IADL) were ascertained with standardized questionnaires. Analyses were adjusted for relevant confounders,
including physical activity. Results across studies were pooled using random-effects meta-analysis.
Results: Meta-analyzed odds ratios (95% confidence interval) per log2 increase in whole blood Se were 0.54
(0.32; 0.76) for weakness, 0.59 (0.34; 0.83) for impaired lower-extremity performance, 0.48 (0.31; 0.68) for
mobility limitations, 0.71 (0.45; 0.97) for agility limitations, and 0.34 (0.12; 0.56) for disability in at least one
IADL. Analyses for serum Se in NHANES showed similar results. Findings suggest the inverse association with
grip strength is progressive below 140 μg/L (p-value for non-linear trend in the Seniors-ENRICA-2 study = 0.13),
and above 140 μg/L (p-value for non-linear trend in NHANES = 0.11). In the Seniors-ENRICA-2 cohort, with a
2.2 year follow-up period, a doubling in baseline Se levels were associated with a lower incidence of weakness
[odds ratio (95% confidence interval): 0.45 (0.22; 0.91)], impaired lower-extremity performance [0.63 (0.32;
1.23)], mobility [0.43 (0.21; 0.91)] and agility [0.38 (0.18; 0.78)] limitations.
Discussion: In US and Spanish older adults, Se concentrations were inversely associated with physical function
limitations. Further studies are needed to elucidate underlying mechanisms.},
organization = {Instituto de Salud Carlos III

European Commission

PI18/287
16/609},
organization = {State Secretary of R + D + I 

PID2019-108973RB-C21/C22},
organization = {European Social Fund (ESF)

European Commission},
publisher = {Elsevier},
keywords = {Biomarkers},
keywords = {Disability},
keywords = {Older adults},
keywords = {Physical performance},
keywords = {Selenium},
title = {Selenium and impaired physical function in US and Spanish older adults},
doi = {10.1016/j.redox.2020.101819},
author = {García Esquinas, E. and Olmedo Palma, Pablo and Gil Hernández, Fernando},
}