@misc{10481/66929,
year = {2021},
url = {http://hdl.handle.net/10481/66929},
abstract = {The seeds of Euphorbia lathyris have been used in traditional medicine to treat various
medical conditions. However, neither all of their active biocompounds nor the molecular mechanisms
underlying their therapeutic effects have been described. A new ethanolic extract of defatted flour
from mature seeds of Euphorbia lathyris showed a high total polyphenol content and significant
antioxidant activity. Chromatographic analysis showed that esculetin, euphorbetin, gaultherin, and
kaempferol-3-rutinoside were the most abundant polyphenolic bioactive compounds. Antiproliferative assays showed a high and selective antitumor activity against colon cancer cell lines (T84
and HCT-15). In addition, a significant antiproliferative activity against glioblastoma multiforme
cells was also demonstrated. Its mechanism of action to induce cell death was mediated by the
overexpression of caspases 9, 3, and 8, and by activation of autophagy. Interestingly, a reduction
in the migration capacity of colon cancer cells and a significant antiangiogenic effect on human
umbilical vein endothelial cells were also demonstrated. Finally, the extract significantly reduced the
subpopulations of cancer stem cells. This extract could be the basis to develop new therapeutic strategies for the treatment of colon cancer, although further experiments will be necessary to determine
its in vivo effects.},
organization = {Granada University (project PSE/17/002), Ministerio de
Ciencia e Innovación (project RTC-2017-6540-1) and by the CTS-107 and AGR145 Groups.},
publisher = {MDPI},
keywords = {Colon cancer},
keywords = {Euphorbia lathyris},
keywords = {Ethanolic extract},
keywords = {Apoptosis},
keywords = {Antiangiogenic effect},
keywords = {Cancer stem cells},
title = {Antitumor Effect of the Ethanolic Extract from Seeds of Euphorbia lathyris in Colorectal Cancer},
doi = {10.3390/nu13020566},
author = {Mesas Hernández, Cristina and Martínez, Rosario and Ortiz Quesada, Raúl and Galisteo Moya, Milagros and López-Jurado Romero De La Cruz, María and Cabeza, Laura and Perazzoli, Gloria and Melguizo Alonso, Consolación and Porres Foulquie, Jesús María and Prados Salazar, José Carlos},
}