@misc{10481/66867,
year = {2021},
month = {1},
url = {http://hdl.handle.net/10481/66867},
abstract = {The application of metallic nanoparticles (materials with size at least in one dimension
ranging from 1 to 100 nm) as a new therapeutic tool will improve the diagnosis and treatment of
diseases. The mitochondria could be a therapeutic target to treat pathologies whose origin lies in
mitochondrial dysfunctions or whose progression is dependent on mitochondrial function. We aimed
to study the subcellular distribution of 2–4 nm iron nanoparticles and its effect on mitochondrial DNA
(mtDNA), mitochondrial function, and autophagy in colorectal cell lines (HT-29). Results showed
that when cells were exposed to ultra-small iron nanoparticles, their subcellular fate was mainly
mitochondria, affecting its respiratory and glycolytic parameters, inducing the migration of the
cellular state towards quiescence, and promoting and triggering the autophagic process. These effects
support the potential use of nanoparticles as therapeutic agents using mitochondria as a target for
cancer and other treatments for mitochondria-dependent pathologies.},
organization = {Government of Asturias through the Science, Technology and Innovation Plan (PCTI) - FEDER funds 

FC-GRUPIN-IDI/2018/000242},
organization = {Spanish Ministry of Economy, Industry and Competitiveness (MINECO) 

CTQ2016-80069-C 2-1R
RTI2018-094605-B-I00},
publisher = {Mdpi},
keywords = {Nanotechnology},
keywords = {Mitochondria},
keywords = {Respiration},
keywords = {mtDNA deletions},
keywords = {Copy number},
keywords = {Metals},
title = {Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration},
doi = {10.3390/pharmaceutics13010090},
author = {Rivas García, Lorenzo and Quiles Morales, José Luis and Varela López, Alfonso and Llopis González, Juan and Sánchez González, Cristina},
}