@misc{10481/66788,
year = {2021},
url = {http://hdl.handle.net/10481/66788},
abstract = {Introduction: Prematurity, a well-established risk factor for various intestinal diseases
in newborns, results in increased morbidity and mortality. However, the intestinal
inflammatory status of preterm (PT) infants has been poorly characterized. Here we have
broadly described the intestinal and systemic inflammatory status of PT children.
Materials and Methods: Meconium and plasma from 39 PT and 32 full term (T)
newborns were studied. Fecal calprotectin, polymorphonuclear leukocyte elastase
(PMN-E), TNF, IL-17A, IL-8, IP-10, MCP-1, MIP-1, IL-1β, IL-1α, and E-selectin and
the enzymatic activities of myeloperoxidase (MPO) and alkaline phosphatase (AP) in
meconium were measured. Plasma levels of AP, hepatocyte growth factor, nerve growth
factor (NGF), proinflammatory cytokines, leptin, adiponectin, PAI-1, and resistin were also
determined. Correlations with gestational age (GA) and birth weight (BW) were studied.
Results: Neutrophil derived PMN-E, MPO and calprotectin were increased in the
meconium of PT compared to T newborns, while AP was decreased. No significant
differences were found in other inflammatory parameters. Considering data from all
children, GA and BW showed inverse correlation with neutrophil markers, while AP
directly correlated with BW. Plasma levels of IL-1β and NGF were enhanced in PT infants,
and were also negatively correlated with BW. PT children additionally showed neutropenia
and decreased adiponectin, leptin, haematocrit, and haemoglobin. These parameters
(neutrophils, adiponectin, and so forth) were positively correlated with GA and BW, while
IL-8, MCP-1, PAI-1, and plasma AP were negatively correlated. PT children showing
postnatal morbidity exhibited increased meconium MPO and MIP-1α.
Conclusion: PT neonates present a significant elevation of intestinal inflammatory
parameters, characterized by the presence of neutrophil markers, associated with mild
systemic inflammation.},
organization = {Ministry of Economy and Competitivity},
organization = {European Commission

SAF2017-88457-R
AGL2017-85270-R
BFU2014-57736-P
AGL2014-58883-R},
organization = {Junta de Andalucia

CTS235
CTS164},
organization = {University of Granada (Contrato Puente Program-Plan Propio)},
organization = {Ministry of Education [Spain]},
organization = {Instituto de Salud Carlos III

European Commission},
publisher = {FRONTIERS MEDIA SA},
keywords = {Intestinal inflammation},
keywords = {Preterm newborns},
keywords = {Birth weight},
keywords = {Gestational age},
keywords = {Neutrophils},
title = {Premature Birth Infants Present Elevated Inflammatory Markers in the Meconium},
doi = {10.3389/fped.2020.627475},
author = {Rodríguez Benítez, María Victoria and Gámez Belmonte, María de los Reyes and Hernández Chirlaque, Cristina and Rodríguez Bouzas, Paula and Martínez Augustín, María Olga},
}