@misc{10481/66710,
year = {2020},
month = {12},
url = {http://hdl.handle.net/10481/66710},
abstract = {Microbiota is defined as the collection of microorganisms within the gastrointestinal
ecosystem. These microbes are strongly implicated in the stimulation of immune responses. An
unbalanced microbiota, termed dysbiosis, is related to the development of several liver diseases. The
bidirectional relationship between the gut, its microbiota and the liver is referred to as the gut–liver
axis. The translocation of bacterial products from the intestine to the liver induces inflammation in
different cell types such as Kupffer cells, and a fibrotic response in hepatic stellate cells, resulting
in deleterious effects on hepatocytes. Moreover, ischemia-reperfusion injury, a consequence of liver
surgery, alters the microbiota profile, affecting inflammation, the immune response and even liver
regeneration. Microbiota also seems to play an important role in post-operative outcomes (i.e., liver
transplantation or liver resection). Nonetheless, studies to determine changes in the gut microbial
populations produced during and after surgery, and affecting liver function and regeneration are
scarce. In the present review we analyze and discuss the preclinical and clinical studies reported in
the literature focused on the evaluation of alterations in microbiota and its products as well as their
effects on post-operative outcomes in hepatic surgery.},
organization = {Ministerio de Ciencia, Innovacion y Universidades (MCIU) Madrid, Spain 	
RTI2018-095114-B-I00},
organization = {European Union (Fondos Feder, "Una manera de hacer Europa")},
organization = {CERCA Program/Generalitat de Catalunya},
organization = {Secretaria d'Universitats i Recerca Barcelona, Spain 	
2017SGR-551},
organization = {COST action Programs 	
CA17103
CA17126},
publisher = {MDPI},
keywords = {Microbiota},
keywords = {Liver transplantation},
keywords = {Partial hepatectomy},
keywords = {Liver surgery},
keywords = {Ischemia-reperfusion},
title = {Effects of Gut Metabolites and Microbiota in Healthy and Marginal Livers Submitted to Surgery},
doi = {10.3390/ijms22010044},
author = {Micó-Carnero, Marc and Rojano-Alfonso, Carlos and Álvarez Mercado, Ana Isabel and Gracia-Sancho, Jordi and Casillas-Ramírez, Araní and Peralta, Carmen},
}