@misc{10481/66632,
year = {2020},
month = {12},
url = {http://hdl.handle.net/10481/66632},
abstract = {Exosomes are lipid bilayer particles released from cells into their surrounding environment.
These vesicles are mediators of near and long-distance intercellular communication and affect various
aspects of cell biology. In addition to their biological function, they play an increasingly important
role both in diagnosis and as therapeutic agents. In this paper, we review recent literature related
to the molecular composition of exosomes, paying special attention to their role in pathogenesis,
along with their application as biomarkers and as therapeutic tools. In this context, we analyze
the potential use of exosomes in biomedicine, as well as the limitations that preclude their wider
application.
Simple Summary: The aim of this review is to provide an overview of the current scientific evidence
concerning the role played by exosomes in the pathogenesis, diagnosis and treatment of diseases.
The potential use of exosomes as delivery vectors for small-molecule therapeutic agents will be
discussed. In addition, a special emphasis will be placed on the involvement of exosomes in
oncological diseases, as well as to their potential therapeutic application as liquid biopsy tools mainly
in cancer diagnosis. A better understanding of exosome biology could improve the results of clinical
interventions using exosomes as therapeutic agents.},
organization = {Spanish ISCIII Health Research Fund},
organization = {European Union (EU)
	
PI12/01097
PI15/02015
PI18/00337
PIE16-00045
DTS19/00145
PI18/00330},
organization = {Ministry of Science, Innovation and Universities (MICIU) 	
RTI2018-101309-B-C22},
organization = {Junta de Andalucia
	
SOMM17/6109/UGR},
organization = {Chair of "Doctors Galera-Requena in cancer stem cell research" 	
CMC-CTS963},
organization = {Junta de Andalucia
	
CARTPI-0001-201},
organization = {CECEyU of the Junta de Andalucia FEDER/European Cohesion Fund (FSE) 	
2016000073391-TRA
2016000073332-TRA
PI57069
PAIDI-Bio326
PI-0014-2016},
organization = {CSyF of the Junta de Andalucia FEDER/European Cohesion Fund (FSE) 	
2016000073391-TRA
2016000073332-TRA
PI57069
PAIDI-Bio326
PI-0014-2016},
organization = {Nicolas Monardes Regional Ministry of Health 	
0006/2018},
organization = {National Center for Scientific and Technical Research (CNRST) 	
2UAE2020},
organization = {Mohammed VI Polytechnic University of Morocco},
publisher = {MDPI},
keywords = {Exosomes},
keywords = {Molecular composition},
keywords = {Cancer pathogenesis},
keywords = {Diagnostic},
keywords = {Therapeutics},
title = {Exosomes: Their Role in Pathogenesis, Diagnosis and Treatment of Diseases},
doi = {10.3390/cancers13010084},
author = {Aheget, Houssam and Mazini, Loubna and Martín Molina, Francisco and Belqat, Boutaïna and Marchal Corrales, Juan Antonio and Benabdellah, Karim},
}