@misc{10481/66551,
year = {2020},
month = {12},
url = {http://hdl.handle.net/10481/66551},
abstract = {Celiac disease (CD) is an autoimmune enteropathy associated with alterations of
metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived
lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism.
To date, no targeted metabolomics analysis investigating di erences in the plasma choline/methionine
metabolome of CD subjects are reported. This work is a targeted metabolomic study that analyzes
37 metabolites of the one-carbon metabolism in 17 children with CD, treated with a gluten-free diet
and 17 healthy control siblings, in order to establish the potential defects in this metabolic network.
Our results demonstrate the persistence of defects in the transsulfuration pathway of CD subjects,
despite dietary treatment, while choline metabolism, methionine cycle, and folate cycle seem to be
reversed and preserved to healthy levels. These findings describe for the first time, a metabolic defect
in one-carbon metabolism which could have profound implications in the physiopathology and
treatment of CD.},
organization = {Junta de Andalucía

P12-AGR-2581},
organization = {Spanish Ministry of Science, Innovation, and Universities (Ministerio de Ciencia, Innovacion y Universidades) 	
RTI2018-099200-BI00},
organization = {Generalitat of Catalonia: Agency for Management of University and Research Grants 	
2017SGR696},
organization = {Department of Health 	
SLT002/16/00250},
organization = {European Union (EU)},
organization = {Grant "Investigation grant program by the SPAO" 2020 edition},
publisher = {Mdpi},
keywords = {Amino acids},
keywords = {Choline},
keywords = {Celiac disease},
keywords = {Folate cycle},
keywords = {Mass spectrometry},
keywords = {Methionine cycle},
keywords = {Methionine savage pathway},
keywords = {Transsulfuration pathway},
title = {Alterations in One-Carbon Metabolism in Celiac Disease},
doi = {10.3390/nu12123723},
author = {Martín Masot, Rafael and Maldonado Lozano, José},
}