@misc{10481/66536,
year = {2020},
url = {http://hdl.handle.net/10481/66536},
abstract = {Abnormal heart rate variability (HRV) has been observed in patients with systemic
lupus erythematosus (SLE). In a combined cross-sectional and interventional study approach,
we investigated the association of HRV with inflammation and oxidative stress markers,
patient-reported outcomes, and the effect of 12 weeks of aerobic exercise in HRV. Fifty-five women
with SLE (mean age 43.5 ± 14.0 years) were assigned to either aerobic exercise (n = 26) or usual care
(n = 29) in a non-randomized trial. HRV was assessed using a heart rate monitor during 10 min,
inflammatory and oxidative stress markers were obtained, psychological stress (Perceived Stress
Scale), sleep quality (Pittsburg Sleep Quality Index), fatigue (Multidimensional Fatigue Inventory),
depressive symptoms (Beck Depression Inventory), and quality of life (36-item Short-Form Health
Survey) were also assessed. Low frequency to high frequency power (LFHF) ratio was associated with
physical fatigue (p = 0.019). Sample entropy was inversely associated with high-sensitivity C-reactive
protein (p = 0.014) and myeloperoxidase (p = 0.007). There were no significant between-group
differences in the changes in HRV derived parameters after the exercise intervention. High-sensitivity
C-reactive protein and myeloperoxidase were negatively related to sample entropy and physical
fatigue was positively related to LFHF ratio. However, an exercise intervention of 12 weeks of aerobic
training did not produce any changes in HRV derived parameters in women with SLE in comparison
to a control group.},
organization = {Fundacion para la Investigacion Biosanitaria de Andalucia Oriental 	
PI-0525-2016
PIER-0223-2019},
organization = {Spanish Ministry of Universities 	
FPU18/01107},
publisher = {MDPI},
keywords = {Autonomic nervous system},
keywords = {Exercise},
keywords = {Inflammation},
keywords = {Fatigue},
keywords = {Rheumatic disease},
title = {Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise},
doi = {10.3390/ijerph17249501},
author = {Martínez Rosales, Elena and Gavilán Carrera, Blanca and Vargas-Hitos, José Antonio and Rosales-Castillo, Antonio and Mario Sabio, José},
}