@misc{10481/66458,
year = {2020},
month = {11},
url = {http://hdl.handle.net/10481/66458},
abstract = {Microbiota is involved in the host blood pressure (BP) regulation. The immunosuppressive
drug mofetil mycophenolate (MMF) ameliorates hypertension. The present study analyzed whether
MMF improves dysbiosis in mineralocorticoid-induced hypertension. MaleWistar rats were assigned
to three groups: untreated (CTR), deoxycorticosterone acetate (DOCA)-salt, and DOCA treated
with MMF for 4 weeks. MMF treatment reduced systolic BP, improved endothelial dysfunction,
and reduced oxidative stress and inflammation in aorta. A clear separation in the gut bacterial
community between CTR andDOCAgroups was found, whereas the cluster belonging toDOCA-MMF
group was found to be intermixed. No changes were found at the phylum level among all experimental
groups. MMF restored the elevation in lactate-producing bacteria found in DOCA-salt joined to an
increase in the acetate-producing bacteria. MMF restored the percentage of anaerobic bacteria in the
DOCA-salt group to values similar to control rats. The improvement of gut dysbiosis was associated
with an enhanced colonic integrity and a decreased sympathetic drive in the gut. MMF inhibited
neuroinflammation in the paraventricular nuclei in the hypothalamus. This study demonstrates for
the first time that MMF reduces gut dysbiosis in DOCA-salt hypertension models. This e ect seems
to be related to its capacity to improve gut integrity due to reduced sympathetic drive in the gut
associated with reduced brain neuroinflammation.},
organization = {Comisión Interministerial de Ciencia y Tecnología, Ministerio de Economía y competitividad 	
SAF2017-84894-R},
organization = {Junta de Andalucía

CTS-164},
organization = {European Union (EU)},
organization = {Ministerio de Economía y Competitividad, Instituto de Salud Carlos III (CIBER-CV), Spain},
organization = {United States Department of Health & Human Services

National Institutes of Health (NIH) - USA

NIH National Heart Lung & Blood Institute (NHLBI)

HL102033},
organization = {European Union (Fondo Europeo de Desarrollo Regional, FEDER, "FEDER una manera de hacer Europa")},
publisher = {Mdpi},
keywords = {Mycophenolate},
keywords = {Gut dysbiosis},
keywords = {Hypertension},
keywords = {Oxidative stress},
keywords = {Inflammation},
keywords = {(Deoxycorticosterone acetate) DOCA-salt model},
title = {Mycophenolate Improves Brain–Gut Axis Inducing Remodeling of Gut Microbiota in DOCA-Salt Hypertensive Rats},
doi = {10.3390/antiox9121199},
author = {Robles Vera, Iñaki and de la Visitación, Néstor and Sánchez, Manuel and Gómez Guzmán, Manuel and Jiménez Moleón, Rosario and Moleón Moya, Javier and González Correa, Cristina and Romero Pérez, Miguel and Duarte Pérez, Juan Manuel},
}