@misc{10481/66427,
year = {2020},
month = {12},
url = {http://hdl.handle.net/10481/66427},
abstract = {Obesity and metabolic syndrome (MetS) are worldwide major health challenges.
The Mediterranean diet (MD) is associated with a better cardiometabolic profile, but these beneficial
e ects may be influenced by genetic variations, modulating the predisposition to obesity or MetS.
The aim was to assess whether interaction e ects occur between an obesity genetic risk score
(obesity-GRS) and the MD on adiposity and MetS in European adolescents. Multiple linear regression
models were used to assess the interaction e ects of an obesity-GRS and the MD on adiposity and
MetS and its components. Interaction e ects between theMDon adiposity and MetS were observed in
both sex groups (p < 0.05). However, those interaction e ects were only expressed in a certain number
of adolescents, when a limited number of risk alleles were present. Regarding adiposity, a total of
51.1% males and 98.7% females had lower body mass index (BMI) as a result of higher MD adherence.
Concerning MetS, only 9.9% of males with higher MD adherence had lower MetS scores. However,
the same e ect was observed in 95.2% of females. In conclusion, obesity-related genotypes could
modulate the relationship between MD adherence and adiposity and MetS in European adolescents;
the interaction e ect was higher in females than in males.},
organization = {Iberus Talent Pre-doctoral fellowships 2018, under the European Union's H2020 research and innovation programme under Marie Sklodowska-Curie grant 	
801586},
organization = {Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, CIBERObn 	
ISCIII-CB15/00043},
organization = {European Union (EU)

FOOD-CT-2005-007034},
organization = {HELENA project},
organization = {Spanish Ministry of Economy and Competitiveness 	
RYC-2010-05957
RYC-2011-09011},
organization = {Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn)},
publisher = {Mdpi},
keywords = {Metabolic syndrome},
keywords = {Mediterranean diet},
keywords = {Genetic risk score},
keywords = {Helena},
keywords = {Adolescents},
keywords = {Sex},
title = {Interaction Effect of the Mediterranean Diet and an Obesity Genetic Risk Score on Adiposity and Metabolic Syndrome in Adolescents: The HELENA Study},
doi = {10.3390/nu12123841},
author = {Seral Cortes, Miguel and Molina Hidalgo, Cristina},
}