@misc{10481/66407,
year = {2020},
month = {12},
url = {http://hdl.handle.net/10481/66407},
abstract = {Congenital cytomegalovirus (CMV) infection induces a clinical syndrome usually associated
with hearing loss. However, the e ect of acquired CVM infection in adults and children has not been
clearly defined. The objective of this review is to critically appraise scientific evidence regarding the
association of acquired CMV infection with postnatal hearing loss or tinnitus. A systematic review
of records reporting sensorineural hearing loss (SNHL) or tinnitus and acquired CMV infection
including articles published in English was performed. Search strategy was limited to human studies
with acquired CMV infection. After screening and quality assessment, nine studies involving 1528
individuals fulfilled the inclusion criteria. A total of 14% of patients with SNHL showed evidence
of previous exposure to CMV, while in individuals without SNHL (controls) the percentage rose
up to 19.3%. SNHL was reported as unilateral or bilateral in 15.3%, and not specified in 84.7% of
cases. The degree of SNHL ranged from mild to profound for both children and adults. None of
the records reported tinnitus. The prevalence of children or adults with acquired SNHL with a
confirmed acquired CMV infection by Polymerase Chain Reaction (PCR) or IgM anti-CMV antibodies
is low. Phenotyping of patients with acquired CMV infection was limited to hearing loss by pure tone
audiometry and no additional audiological testing was performed in most of the studies. Additional
symptoms deserve more attention, including episodic vertigo or tinnitus, since some patients with
the clinical spectrum of Meniere Disease could result from a CMV latent infection.},
organization = {Instituto de Salud Carlos III},
organization = {European Regional Funds 	
PI17/1644
PE-0356-2018},
organization = {"IN VITRO PRECLINICAL TRIAL AND MONITORIN OF CLINICAL RESPONSE IN PATIENTS WITH MENIERE DISEASE (CLINMON)" from Andalusian Health Government 	
PE-0356-2018},
organization = {Instituto de Salud Carlos III

FI18/00228},
publisher = {Mdpi},
keywords = {Cytomegalovirus},
keywords = {Sensorineural hearing loss},
keywords = {Tinnitus},
keywords = {Systematic review},
title = {A Systematic Review on the Association of Acquired Human Cytomegalovirus Infection with Hearing Loss},
doi = {10.3390/jcm9124011},
author = {Martínez Gómez, Estrella and Pérez Carpena, Patricia and Flook, Marisa and López Escámez, José Antonio},
}