@misc{10481/66399,
year = {2020},
month = {11},
url = {http://hdl.handle.net/10481/66399},
abstract = {Non-canonical, four-stranded nucleic acids secondary structures are present within
regulatory regions in the human genome and transcriptome. To date, these quadruplex structures
include both DNA and RNA G-quadruplexes, formed in guanine-rich sequences, and i-Motifs, found
in cytosine-rich sequences, as their counterparts. Quadruplexes have been extensively associated
with cancer, playing an important role in telomere maintenance and control of genetic expression of
several oncogenes and tumor suppressors. Therefore, quadruplex structures are considered attractive
molecular targets for cancer therapeutics with novel mechanisms of action. In this review, we provide
a general overview about recent research on the implications of quadruplex structures in cancer,
firstly gathering together DNA G-quadruplexes, RNA G-quadruplexes as well as DNA i-Motifs.},
organization = {3TR, IMI2 	
H2020-JTI538 IMI2-2018},
organization = {Instituto de Salud Carlos III

AC18/00008},
organization = {Government of Spain 	
FPU16/05822},
publisher = {Mdpi},
keywords = {DNA G-quadruplex},
keywords = {RNA G-quadruplex},
keywords = {i-Motif},
keywords = {Cancer},
title = {An Updated Focus on Quadruplex Structures as Potential Therapeutic Targets in Cancer},
doi = {10.3390/ijms21238900},
author = {Sánchez Martin, Victoria and López Pujante, Carmen and Soriano Rodríguez, Miguel and García Salcedo, José A.},
}