@misc{10481/66260,
year = {2020},
month = {11},
url = {http://hdl.handle.net/10481/66260},
abstract = {Background: Pain has been associated with structural changes of the brain. However,
evidence regarding white matter changes in response to acute pain protocols is still
scarce. In the present study, we assess the existence of differences in brain white matter
related to pain intensity reported by patients undergoing surgical removal of a mandibular
impacted third molar using diffusion tensor imaging (DTI) analysis.
Methods: 30 participants reported their subjective pain using a visual analog scale at
three postsurgical stages: under anesthesia, in pain, and after the administration of an
analgesic. The diffusion data were acquired prior to surgery.
Results: DTI analysis yielded significant positive associations of fractional anisotropy
in white matter areas related to pain processing (corticospinal tract, corona radiata,
corpus callosum) with the differences in pain between the three postsurgery stages.
Extent and location of these associations depended on the magnitude of the subjective
pain differences. Tractography analysis indicated that some pain–tract associations are
significant only when pain stage is involved in the contrast (posterior corona radiata),
while others (middle cerebellar peduncle, pontine crossing) are only when anesthesia is
involved in the contrast.
Conclusions: The association of white matter fractional anisotropy and connectivity,
measured before the pain stages, with subjective pain depends on the magnitude of the
differences in pain scores.},
organization = {Junta de Andalucía

CTS-138
CTS-176
CTS-1028},
organization = {Talentia Scholarship Program of the Regional Ministry for Innovation, Science, and Enterprise (Junta de Andalucía)},
organization = {Spanish Ministry of Economy and Competitiveness 	
PSI2012-39292},
organization = {Andalucia Talent Hub Program from the Andalusian Knowledge Agency},
organization = {European Union (EU)

291780},
organization = {Ministry of Economy, Innovation, Science and Employment of the Junta de Andalucia},
publisher = {Frontiers Media SA},
keywords = {Analgesia},
keywords = {Trends},
keywords = {Anesthesia},
keywords = {Acute pain},
keywords = {Tractography},
keywords = {Fractional anisotropy},
keywords = {White matter structure},
title = {On the Relationship Between White Matter Structure and Subjective Pain. Lessons From an Acute Surgical Pain Model},
doi = {10.3389/fnhum.2020.558703},
author = {Torrecillas-Martínez, Laura and Catena Martínez, Andrés and O'Valle Ravassa, Francisco Javier and Solano Galvis, César Augusto and Padial Molina, Miguel and Galindo Moreno, Pablo Antonio},
}