@misc{10481/66178,
year = {2020},
url = {http://hdl.handle.net/10481/66178},
abstract = {The main aim of this study was to generate an adequate sub-phenotypic clustering model of class
III skeletal malocclusion in an adult population of southern European origin. The study design was
conducted in two phases, a preliminary cross-sectional study and a subsequent discriminatory
evaluation by main component and cluster analysis to identify diferentiated skeletal sub-groups
with diferentiated phenotypic characteristics. Radiometric data from 699 adult patients of southern
European origin were analyzed in 212 selected subjects afected by class III skeletal malocclusion. The
varimax rotation was used with Kaiser normalization, to prevent variables with more explanatory
capacity from afecting the rotation. A total of 21,624 radiographic measurements were obtained
as part of the cluster model generation, using a total set of 55 skeletal variables for the subsequent
analysis of the major component and cluster analyses. Ten main axes were generated representing
92.7% of the total variation. Three main components represented 58.5%, with particular sagittal and
vertical variables acting as major descriptors. Post hoc phenotypic clustering retrieved six clusters:
C1:9.9%, C2:18.9%, C3:33%, C4:3.77%, C5:16%, and C6:16%. In conclusion, phenotypic variation
was found in the southern European skeletal class III population, demonstrating the existence of
phenotypic variations between identifed clusters in diferent ethnic groups.},
publisher = {NATURE RESEARCH},
keywords = {Craniofacial complex},
keywords = {Gene therapy},
keywords = {Growth},
keywords = {Prediction},
keywords = {Association},
keywords = {Children},
keywords = {Adults},
title = {Sub-clustering in skeletal class III malocclusion phenotypes via principal component analysis in a southern European population},
doi = {10.1038/s41598-020-74488-w},
author = {De Frutos-Valle, Leixuri and Alarcón Pérez, José Antonio},
}