@misc{10481/65989,
year = {2020},
month = {11},
url = {http://hdl.handle.net/10481/65989},
abstract = {Nearly half of the human genome is made of transposable elements (TEs) whose activity
continues to impact its structure and function. Among them, Long INterspersed Element class
1 (LINE-1 or L1) elements are the only autonomously active TEs in humans. L1s are expressed
and mobilized in different cancers, generating mutagenic insertions that could affect tumor
malignancy. Tumor suppressor microRNAs are ∼22nt RNAs that post-transcriptionally regulate
oncogene expression and are frequently downregulated in cancer. Here we explore
whether they also influence L1 mobilization. We show that downregulation of let-7 correlates
with accumulation of L1 insertions in human lung cancer. Furthermore, we demonstrate that
let-7 binds to the L1 mRNA and impairs the translation of the second L1-encoded protein,
ORF2p, reducing its mobilization. Overall, our data reveals that let-7, one of the most relevant
microRNAs, maintains somatic genome integrity by restricting L1 retrotransposition.},
organization = {European Research Council (ERC)

ERC-2009-StG 243312},
organization = {French National Research Agency (ANR)

ANR-11-LABX-0028-01
ANR-15-IDEX-01},
organization = {Centre National de la Recherche Scientifique (CNRS)

3546},
organization = {University Hospital Federation (FHU) OncoAge},
organization = {MINECO 	
PEJ-2014-A-31985
SAF2015-71589-P},
organization = {MINECO by European Regional Development Fund 	
SAF2015-71589-P},
organization = {Spanish Government

RYC-2016-21395},
organization = {Career Integration Grant-Marie Curie 	
FP7-PEOPLE-2011-CIG-303812},
publisher = {Nature Research},
title = {The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition},
doi = {10.1038/s41467-020-19430-4},
author = {Rubio Roldan, Alejandro and Peris, Guillermo and Sánchez, Laura and Tristán Ramos, Pablo and Amador Cubero, Suyapa and Rodríguez Heras, Sara},
}