@misc{10481/65493,
year = {2020},
month = {10},
url = {http://hdl.handle.net/10481/65493},
abstract = {Several anticancer properties have been largely attributed to phenolics in in vivo and
in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been
studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between
the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its
anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain)
obtained from di erent regions of Spain. We included 2700 controls and 329 GC cases. Odds
ratios (ORs) were calculated using mixed e ects logistic regression considering quartiles of phenolic
intake. Our results showed an inverse association between stilbene and lignan intake and GC risk
(ORQ4 vs. Q1 = 0.47; 95% CI: 0.32–0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36–0.77, respectively). We
found no overall association between total phenolic acid and other polyphenol class intake and GC
risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28–0.61), hydroxycoumarins
(ORQ4 vs. Q1 = 0.49; 95% CI: 0.34–0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39–0.80) were
inversely associated with GC risk. No di erences were found in the analysis by anatomical or
histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes,
hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies
are needed to confirm our results.},
organization = {Instituto de Salud Carlos III},
organization = {Instituto de Salud Carlos III

European Union (EU)

PI08/1770
PI08/0533
PI08/1359
PS09/00773-Cantabria
PS09/01286-Leon
PS09/01903-Valencia
PS09/02078-Huelva
PS09/01662-Granada
PI11/01403
PI11/01889-FEDER
PI11/00226
PI11/01810
PI11/02213
PI12/00488},
organization = {Instituto de Salud Carlos III

API 10/09},
organization = {ICGC International Cancer Genome Consortium CLL (Spanish Ministerio de Economia y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII))},
organization = {ICGC International Cancer Genome Consortium CLL (Spanish Ministerio de Economia y Competitividad (MINECO) through Red Tematica de Investigacion del Cancer (RTICC) del ISCIII) 	
RD12/0036/0036},
organization = {Junta de Castilla y León

LE22A10-2},
organization = {Junta de Andalucía

PI-0571-200
PI-0306-2011
salud201200057018tra},
organization = {Conselleria de Sanitat of the Generalitat Valenciana 	
AP_061/10},
organization = {La Caixa Foundation

2010ACUP 00310},
organization = {Regional Government of the Basque Country},
organization = {Consejería de Sanidad de la Región de Murcia},
organization = {European Commission

European Commission Joint Research Centre

FOOD-CT-2006-036224-HIWATE},
organization = {Spanish Association Against Cancer (AECC) Scientific Foundation},
organization = {Catalan Government Agency for Management of University and Research Grants (AGAUR) grants 	
2017SGR723
2014SGR850},
organization = {Fundación Caja de Ahorros de Asturias},
organization = {University of Oviedo},
organization = {"Miguel Servet" program from the Institute of Health Carlos III (European Social Fund (ESF)-ESF investing in your future) 	
CP15/00100},
organization = {Ministry of Education of Spain 	
FPU17/06488},
organization = {University of Leon},
organization = {Spanish Ministry of Science and Innovation through the "Centro de Excelencia Severo Ochoa 2019-2023" Program 	
CEX2018-000806-S},
organization = {Generalitat de Catalunya through the CERCA Program},
organization = {The Instituto de Salud Carlos III-FEDER 	
PI12/00265
PI12/01270
PI12/00715
PI12/00150
PI14/01219
PI14/0613
PI15/00069
PI15/00914
PI15/01032
PI17CIII/00034},
publisher = {Mdpi},
keywords = {Diet},
keywords = {Epidemiology},
keywords = {Gastric cancer},
keywords = {Polyphenols},
keywords = {Phenolic acids},
keywords = {Stilbenes},
keywords = {Lignans},
keywords = {Anatomic},
keywords = {Histologic},
keywords = {MCC-Spain},
title = {Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain},
doi = {10.3390/nu12113281},
author = {Rubín García, María and Jiménez Moleón, José Juan},
}