@misc{10481/65026,
year = {2020},
month = {11},
url = {http://hdl.handle.net/10481/65026},
abstract = {Rejection-associated gene expression has been characterized in renal allograft biopsies
for cause. The aim is to evaluate rejection gene expression in subclinical rejection and in biopsies
with borderline changes or interstitial fibrosis and tubular atrophy (IFTA).We included 96 biopsies.
Most di erentially expressed genes between normal surveillance biopsies (n = 17) and clinical rejection
(n = 12) were obtained. A rejection-associated gene (RAG) score was defined as its geometric mean.
The following groups were considered: (a) subclinical rejection (REJ-S, n = 6); (b) borderline changes
in biopsies for cause (BL-C, n = 13); (c) borderline changes in surveillance biopsies (BL-S, n = 12);
(d) IFTA in biopsies for cause (IFTA-C, n = 20); and (e) IFTA in surveillance biopsies (IFTA-S, n = 16).
The outcome variable was death-censored graft loss or glomerular filtration rate decline   30 %
at 2 years. A RAG score containing 109 genes derived from normal and clinical rejection (area
under the curve, AUC = 1) was employed to classify the study groups. A positive RAG score was
observed in 83% REJ-S, 38% BL-C, 17% BL-S, 25% IFTA-C, and 5% IFTA-S. A positive RAG score was
an independent predictor of graft outcome from histological diagnosis (hazard ratio: 3.5 and 95%
confidence interval: 1.1–10.9; p = 0.031). A positive RAG score predicts graft outcome in surveillance
and for cause biopsies with a less severe phenotype than clinical rejection.},
organization = {Red de Investigacion Renal 	
REDinREN RD16/0009/0030},
organization = {Instituto de Salud Carlos III

PI 18/01704
PI 18/01382},
organization = {Sociedad Espanola de Trasplante},
organization = {Vall d'Hebron Institute of Research (VHIR) grant},
publisher = {Mdpi},
keywords = {Renal transplantation},
keywords = {Biopsies},
keywords = {Rejection},
keywords = {Transcriptomics},
keywords = {Microarrays},
keywords = {Borderline changes},
keywords = {Interstitial fibrosis and tubular atrophy},
title = {A Rejection Gene Expression Score in Indication and Surveillance Biopsies Is Associated with Graft Outcome},
doi = {10.3390/ijms21218237},
author = {Chamoun, Betty and O'Valle Ravassa, Francisco Javier},
}