@misc{10481/64978, year = {2010}, url = {http://hdl.handle.net/10481/64978}, abstract = {Mediterranean countries have lower rates of mortality from cardiovascular disease and cancer than Northern European or other Western countries. This has been attributed, at least in part,tothe so-called Mediterranean diet, which is composed of specific local foods, including olive oil. Traditionally, many beneficial properties associated with this oil have been ascribed to its high oleic acid content. Today, it is clear that many of the beneficial effects of ingesting virgin olive oil are due to its minor compounds. This review summarizes the existing knowledge concerning the chemistry, pharmacokinetics, and toxicology of hydroxytyrosol, a minor compound of virgin olive oil, as well as this compound's importance for health. The main findings in terms of its beneficial effects in cardiovascular disease and cancer, including its properties against inflammation and platelet aggregation, are emphasized. New evidence and strategies regarding the use of hydroxytyrosol as a natural drug for the prevention and treatment of diseases with high incidences in Western countries are also presented.}, organization = {Excelentisima Diputacion de Jaen, CEAS Foundation 30.C0.244500}, organization = {Junta de Andalucia PI-0210/2007}, organization = {Spanish Government AP2005-144}, publisher = {OXFORD UNIV PRESS INC}, keywords = {Cardiovascular disease}, keywords = {Cancer}, keywords = {Hydroxytyrosol}, keywords = {Mediterranean diet}, keywords = {Olive oil}, title = {Hydroxytyrosol: from laboratory investigations to future clinical trials}, doi = {10.1111/j.1753-4887.2010.00278.x}, author = {Granados Principal, Sergio and Ramírez Tortosa, María Carmen and Quiles Morales, José Luis}, }