@misc{10481/64969,
year = {2017},
url = {http://hdl.handle.net/10481/64969},
abstract = {Conventional cardiovascular risk factors (CVRF) are accepted to identify asymptomatic
individuals with high risk of acute myocardial infarction (AMI). However, AMI affects
many patients previously classified at low risk. New biomarkers are needed to improve
risk prediction. We propose to evaluate the NLRP3-inflammasome complex as a
potential CVR indicator in healthy males and post-AMI patients and compare both
groups by known CVRFs. We included 109 men with no history of cardiovascular
disease (controls) and 150 AMI patients attending a cardiac rehabilitation program.
AMI patients had higher mean of BMI and waist circumference than the controls.
However, high percentages of the controls had a high BMI and a waist circumference
>95 cm. The controls also had higher systolic blood pressure (P>0.001), total and LDLcholesterol, dietary nutrient and calorific intake. Fuster BEWAT Score (FBS) correlated
more closely than Framingham risk score (FRS) with most CVRF, groups. However,
only the FBS showed a correlation with inflammasome cytokine IL-1β. Several
conventional CVRFs were significantly better in AMI patients; however, this group also
had higher mRNA expression of the inflammasome gene NLRP3 and lower expression
of the autophagy gene MAP-LC3. The controls had high levels of CVRF, probably
reflecting unhealthy lifestyle. FBS reflects the efficiency of strategies to induce lifestyle
changes such as cardiac rehabilitation programs, and could provide a sensitive
evaluation cardiovascular risk. These results lead to the hypothesis that NLRP3-
inflammasome and associated IL-1β release have potential as CVR biomarkers,
particularly in post-AMI patients with otherwise low risk scores.},
organization = {Andalusian regional government (Grupo de Investigacion Junta de Andalucia) 	
CTS113
Consejeria de Salud de la Junta de Andalucia: PI-0036-2014},
publisher = {MARY ANN LIEBERT},
keywords = {NLRP3-inflammasome complex},
keywords = {Cardiovascular risk factors},
keywords = {Framingham Risk Score},
keywords = {Fuster BEWAT Score},
title = {Could NLRP3-inflammasome be a cardiovascular risk biomarkers in Acute Myocardial Infarction Patients?},
doi = {10.1089/ars.2016.6970},
author = {Bullón, Pedro and Varela López, Alfonso and Quiles Morales, José Luis},
}