@misc{10481/64927,
year = {2020},
month = {9},
url = {http://hdl.handle.net/10481/64927},
abstract = {Asthma is a multifactorial condition where patients with identical clinical
diagnoses do not have the same clinical history or respond to treatment. This clinical heterogeneity is
reflected in the definition of two main endotypes. We aimed to explore the metabolic and microbiota
signatures that characterize the clinical allergic asthma phenotype in obese children. Methods:
We used a multi-omics approach combining clinical data, plasma and fecal inflammatory biomarkers,
metagenomics, and metabolomics data in a cohort of allergic asthmatic children. Results: We observed
that the obese allergic asthmatic phenotype was markedly associated with higher levels of leptin and
lower relative proportions of plasma acetate and a member from the Clostridiales order. Moreover,
allergic children with a worse asthma outcome showed higher levels of large unstained cells, fecal D
lactate and D/L lactate ratio, and with a higher relative proportion of plasma creatinine and an
unclassified family member from the RF39 order belonging to the Mollicutes class. Otherwise, children
with persistent asthma presented lower levels of plasma citrate and dimethylsulfone. Conclusion:
Our integrative approach shows the molecular heterogeneity of the allergic asthma phenotype while
highlighting the use of omics technologies to examine the clinical phenotype at a more holistic level.},
organization = {Fundación Progreso y Salud Project 	
PI-0373-2014},
organization = {Redes temáticas de investigación cooperativa RETIC 	
Red SAMID RD12/0026/0015},
publisher = {Mdpi},
keywords = {Asthma},
keywords = {Gastrointestinal microbiome},
keywords = {Metabolomics},
keywords = {Multi-omics approach},
title = {A Multi-Omics Approach Reveals New Signatures in Obese Allergic Asthmatic Children},
doi = {10.3390/biomedicines8090359},
author = {Gómez Llorente, Mª Amelia and Martínez Cañavate, Ana and Chueca Porcuna, Natalia and Rico Prados, María Cruz and Romero, Raquel and Morillo, José Antonio and Camacho Páez, José and Gómez Llorente, Carolina},
}