@misc{10481/64901,
year = {2015},
url = {http://hdl.handle.net/10481/64901},
abstract = {An adequate pancreatic structure is necessary for optimal organ function.
Structural changes are critical in the development of age-related pancreatic disorders.
In this context, it has been reported that different pancreatic compartments from rats were
affected according to the fat composition consumed. Since there is a close relationship
between mitochondria, oxidative stress and aging, an experimental approach has been
developed to gain more insight into this process in the pancreas. A low dosage of coenzyme
Q was administered life-long in rats in order to try to prevent pancreatic aging-related alterations associated to some dietary fat sources. According to that, three groups of rats
were fed normocaloric diets containing Coenzyme Q (CoQ) for two years, where virgin
olive, sunflower, or fish oil was included as unique fat source. Pancreatic samples for
microscopy and blood samples were collected at the moment of euthanasia. The main finding
is that CoQ supplementation gives different results according to fat used in diet. When
sunflower oil was the main fat in the diet, CoQ supplementation seems to improve endocrine
pancreas structure and in particular β-cell mass resembling positive effects of virgin olive oil.
Conversely, CoQ intake does not seem to improve the structural alterations of exocrine
compartment previously observed in fish oil fed rats. Therefore CoQ may improve pancreatic
alterations associated to the chronic intake of some dietary fat sources.},
organization = {Spanish Government

AGL2008-01057},
organization = {Autonomous Government of Andalucia 	
AGR832},
organization = {German Research Foundation (DFG)},
organization = {Generalitat Valenciana

APOSTD/2012/021},
publisher = {MDPI},
keywords = {β-cell},
keywords = {Endocrine pancreas},
keywords = {Exocrine pancreas},
keywords = {Inflammation},
keywords = {Pancreatic aging},
keywords = {Pancreatic fibrosis of the elderly},
keywords = {Fats},
keywords = {Dietary lipids},
title = {Sunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after Life-Long Coenzyme Q Addition},
doi = {10.3390/ijms161023425},
author = {González-Alonso, Adrián and Varela López, Alfonso and Ramírez Tortosa, María Carmen and Ochoa Herrera, Julio José and Quiles Morales, José Luis},
}