@misc{10481/64889,
year = {2020},
month = {9},
url = {http://hdl.handle.net/10481/64889},
abstract = {Inorganic hydrogels formulated with spring waters and clay minerals are used to treat
musculoskeletal disorders and skin a ections. Their underlying mechanism of action for skin
disorders is not clear, although it is usually ascribed to the chemical composition of the formulation.
The aim of this study was to assess the composition and in vitro release of elements with potential
wound healing e ects from hydrogels prepared with two nanoclays and natural spring water. In vitro
Franz cell studies were used and the element concentration was measured by inductively coupled
plasma techniques. Biocompatibility studies were used to evaluate the potential toxicity of the
formulation against fibroblasts. The studied hydrogels released elements with known therapeutic
interest in wound healing. The released ratios of some elements, such as Mg:Ca or Zn:Ca, played
a significant role in the final therapeutic activity of the formulation. In particular, the proliferative
activity of fibroblasts was ascribed to the release of Mn and the Zn:Ca ratio. Moreover, the importance
of formulative studies is highlighted, since it is the optimal combination of the correct ingredients
that makes a formulation e ective.},
organization = {Instituto de Salud Carlos III

Spanish Government

CGL2016-80833-R},
organization = {Junta de Andalucía

P18-RT-3786},
organization = {Ministerio de Educación, Cultura y Deporte 	
FPU15/01577},
publisher = {Mdpi},
keywords = {Sepiolite},
keywords = {Palygorksite},
keywords = {Spring water},
keywords = {Hydrogel},
keywords = {Wound healing},
keywords = {Proliferation},
keywords = {Franz cell},
keywords = {Bioactive elements},
title = {Correlation between Elemental Composition/Mobility and Skin Cell Proliferation of Fibrous Nanoclay/Spring Water Hydrogels},
doi = {10.3390/pharmaceutics12090891},
author = {García Villén, Fátima and Sánchez Espejo, Rita María and Borrego Sánchez, Ana and Viseras Iborra, César Antonio},
}