@misc{10481/64756,
year = {2020},
month = {8},
url = {http://hdl.handle.net/10481/64756},
abstract = {The growing incidence of cardiovascular disease (CVD) has promoted investigations of
natural molecules that could prevent and treat CVD. Among these, hydroxytyrosol, a polyphenolic
compound of olive oil, is well known for its antioxidant, anti-inflammatory, and anti-atherogenic
e ects. Its strong antioxidant properties are due to the scavenging of radicals and the stimulation of
synthesis and activity of antioxidant enzymes (SOD, CAT, HO-1, NOS, COX-2, GSH), which also limit
the lipid peroxidation of low-density lipoprotein (LDL) cholesterol, a hallmark of atherosclerosis.
Lowered inflammation and oxidative stress and an improved lipid profile were also demonstrated in
healthy subjects as well as in metabolic syndrome patients after hydroxytyrosol (HT) supplementation.
These results might open a new therapeutic scenario through personalized supplementation of HT in
CVDs. This review is the first attempt to collect together scientific literature on HT in both in vitro
and in vivo models, as well as in human clinical studies, describing its potential biological e ects for
cardiovascular health.},
publisher = {Mdpi},
keywords = {Hydroxytyrosol},
keywords = {Cardiovascular disease},
keywords = {Atherosclerosis},
keywords = {Oxidative stress},
keywords = {Inflammation},
keywords = {Mediterranean diet},
title = {Wide Biological Role of Hydroxytyrosol: Possible Therapeutic and Preventive Properties in Cardiovascular Diseases},
doi = {10.3390/cells9091932},
author = {D’Angelo, Chiara and Franceschelli, Sara and Quiles Morales, José Luis and Speranza, Lorenza},
}