@misc{10481/64736,
year = {2020},
month = {8},
url = {http://hdl.handle.net/10481/64736},
abstract = {A nutritional growth retardation study, which closely resembles the nutritional observations
in children who consumed insu cient total energy to maintain normal growth, was conducted.
In this study, a nutritional stress in weanling rats placed on restricted balanced diet for 4 weeks is
produced, followed by a food recovery period of 4 weeks using two enriched diets that di er mainly
in the slow (SDC) or fast (RDC) digestibility and complexity of their carbohydrates. After re-feeding
with the RDC diet, animals showed the negative e ects of an early caloric restriction: an increase in
adiposity combined with poorer muscle performance, insulin resistance and, metabolic inflexibility.
These e ects were avoided by the SDC diet, as was evidenced by a lower adiposity associated with
a decrease in fatty acid synthase expression in adipose tissue. The improved muscle performance
of the SDC group was based on an increase in myocyte enhancer factor 2D (MEF2D) and creatine
kinase as markers of muscle di erentiation as well as better insulin sensitivity, enhanced glucose
uptake, and increased metabolic flexibility. In the liver, the SDC diet promoted glycogen storage and
decreased fatty acid synthesis. Therefore, the SDC diet prevents the catch-up fat phenotype through
synergistic metabolic adaptations in adipose tissue, muscle, and liver. These coordinated adaptations
lead to better muscle performance and a decrease in the fat/lean ratio in animals, which could prevent
long-term negative metabolic alterations such as obesity, insulin resistance, dyslipidemia, and liver
fat deposits later in life.},
organization = {Abbott Laboratories S.A.},
publisher = {Mdpi},
keywords = {Catch-up growth},
keywords = {Catch-up fat phenotype},
keywords = {Insulin-resistance},
keywords = {Metabolic flexibility},
keywords = {Slow digesting carbohydrates},
title = {Dietary Complex and Slow Digestive Carbohydrates Prevent Fat Deposits During Catch-Up Growth in Rats},
doi = {10.3390/nu12092568},
author = {Salto González, Rafael and Girón González, María Dolores and Ortiz Moral, Carolina and Manzano, Manuel and Vílchez, Jose D and Reche Pérez, Francisco José and Bueno Vargas, Pilar and Rueda, Ricardo and López Pedrosa, José Manuel},
}