@misc{10481/64676,
year = {2020},
month = {9},
url = {http://hdl.handle.net/10481/64676},
abstract = {The genus Enterococcus comprises a ubiquitous group of Gram-positive bacteria that can
cause diverse health care-associated infections. Their genome plasticity enables easy acquisition of
virulence factors as well as antibiotic resistances. Urinary tract infections (UTIs) and catheter-associated
UTIs are common diseases caused by enterococci. In this study, Enterococcus strains isolated from UTIs
were characterized, showing that the majority were E. faecalis and contained several virulence factors
associated to a better colonization of the urinary tract. Their susceptibility against the bacteriocin
AS-48 and several antibiotics was tested. AS-48 is a potent circular bacteriocin that causes bacterial
death by pore formation in the cell membrane. The interest of this bacteriocin is based on the potent
inhibitory activity, the high stability against environmental conditions, and the low toxicity. AS-48
was active at concentrations below 10 mg/L even against antibiotic-resistant strains, whereas these
strains showed resistance to, at least, seven of the 20 antibiotics tested. Moreover, the e ect of AS-48
combined with antibiotics commonly used to treat UTIs was largely synergistic (with up to 100-fold
MIC reduction) and only occasionally additive. These data suggest AS-48 as a potential novel drug to
deal with or prevent enterococcal infections.},
organization = {Spanish Ministry of Economy and Competitiveness 	
SAF2013-48971-C2-1-R},
organization = {European Union (EU)},
organization = {Research Group General (UGR) 	
BIO160},
publisher = {Mdpi},
keywords = {Enterococcus},
keywords = {VRE},
keywords = {Virulence},
keywords = {Antibiotic resistance},
keywords = {Antimicrobial peptide},
title = {Synergy of the Bacteriocin AS-48 and Antibiotics against Uropathogenic Enterococci},
doi = {10.3390/antibiotics9090567},
author = {Montalbán López, Manuel and Cebrián, Rubén and Galera, Rosa and Mingorance, Lidia and Martín Platero, Antonio Manuel and Valdivia Martínez, Dolores Eva and Martínez Bueno, Manuel and Maqueda Abreu, Mercedes},
}