@misc{10481/64544,
year = {2020},
url = {http://hdl.handle.net/10481/64544},
abstract = {Exocrine pancreatic insufficiency (EPI) is defined as the maldigestion of foods due to
inadequate pancreatic secretion, which can be caused by alterations in its stimulation, production,
transport, or interaction with nutrients at duodenal level. The most frequent causes are chronic
pancreatitis in adults and cystic fibrosis in children. The prevalence of EPI is high, varying according
to its etiology, but it is considered to be underdiagnosed and undertreated. Its importance lies in the
quality of life impairment that results from the malabsorption and malnutrition and in the increased
morbidity and mortality, being associated with osteoporosis and cardiovascular events. The diagnosis
is based on a set of symptoms, indicators of malnutrition, and an indirect non-invasive test in at-risk
patients. The treatment of choice combines non-restrictive dietary measures with pancreatic enzyme
replacement therapy to correct the associated symptoms and improve the nutritional status of patients.
Non-responders require the adjustment of pancreatic enzyme therapy, the association of proton pump
inhibitors, and/or the evaluation of alternative diagnoses such as bacterial overgrowth. This review
offers an in-depth overview of EPI in order to support the proper management of this entity based on
updated and integrated knowledge of its etiopathogenesis, prevalence, diagnosis, and treatment.},
organization = {Junta de Andalucia

PC-0498-2017
PC-0549-2017},
publisher = {MDPI},
keywords = {Exocrine pancreatic insufficiency},
keywords = {Prevalence},
keywords = {Clinic relevance},
keywords = {Diagnosis},
keywords = {Treatment},
keywords = {Pancreatic enzyme replacement therapy},
title = {State of the Art in Exocrine Pancreatic Insufficiency},
doi = {10.3390/medicina56100523},
author = {Diéguez Castillo, Carmelo and Jiménez Luna, Cristina and Prados Salazar, José Carlos and Martín Ruiz, José Luis and Caba Pérez, Octavio},
}