@misc{10481/64481,
year = {2016},
url = {http://hdl.handle.net/10481/64481},
abstract = {Colon cancer is one of the most prevalent diseases across the world. Numerous epidemiological
studies indicate that diets rich in fruit, such as berries, provide significant health benefits against
several types of cancer, including colon cancer. The anticancer activities of berries are attributed
to their high content of phytochemicals and to their relevant antioxidant properties. In vitro and
in vivo studies have demonstrated that berries and their bioactive components exert therapeutic
and preventive effects against colon cancer by the suppression of inflammation, oxidative stress,
proliferation and angiogenesis, through the modulation of multiple signaling pathways such as
NF-κB, Wnt/β-catenin, PI3K/AKT/PKB/mTOR, and ERK/MAPK. Based on the exciting outcomes
of preclinical studies, a few berries have advanced to the clinical phase. A limited number of human
studies have shown that consumption of berries can prevent colorectal cancer, especially in patients
at high risk (familial adenopolyposis or aberrant crypt foci, and inflammatory bowel diseases). In this
review, we aim to highlight the findings of berries and their bioactive compounds in colon cancer
from in vitro and in vivo studies, both on animals and humans. Thus, this review could be a useful
step towards the next phase of berry research in colon cancer.},
publisher = {MDPI},
keywords = {Berry},
keywords = {Chemoprevention},
keywords = {Colon cancer},
keywords = {Polyphenol},
keywords = {Bioactive compound},
title = {Chemopreventive and Therapeutic Effects of Edible Berries: A Focus on Colon Cancer Prevention and Treatment},
doi = {10.3390/molecules21020169},
author = {Afrin, Sadia and Varela López, Alfonso and Quiles Morales, José Luis},
}