@misc{10481/64398,
year = {2020},
url = {http://hdl.handle.net/10481/64398},
abstract = {The experimental determination of the relative biological effectiveness of thermal neutron
factors is fundamental in Boron Neutron Capture Therapy. The present values have been obtained
while using mixed beams that consist of both neutrons and photons of various energies. A common
weighting factor has been used for both thermal and fast neutron doses, although such an approach has
been questioned. At the nuclear reactor of the Institut Laue-Langevin a pure low-energy neutron beam
has been used to determine thermal neutron relative biological effectiveness factors. Different cancer
cell lines, which correspond to glioblastoma, melanoma, and head and neck squamous cell carcinoma,
and non-tumor cell lines (lung fibroblast and embryonic kidney), have been irradiated while using
an experimental arrangement designed to minimize neutron-induced secondary gamma radiation.
Additionally, the cells were irradiated with photons at a medical linear accelerator, providing reference
data for comparison with that from neutron irradiation. The survival and proliferation were studied
after irradiation, yielding the Relative Biological Effectiveness that corresponds to the damage of
thermal neutrons for the different tissue types.},
organization = {Asociacion Espanola Contra el Cancer (AECC) 	
PS16163811PORR},
organization = {Spanish MINECO 	
FIS2015-69941-C2-1-P},
organization = {Junta de Andalucia

P11-FQM-8229},
organization = {Campus of International Excellence BioTic 	
P-BS-64},
organization = {University of Granada Chair Neutrons for Medicine: the Spanish Fundacion ACS},
organization = {Asociacion Capitan Antonio},
organization = {Fundacion ACS},
organization = {La Kuadrilla de Iznalloz},
organization = {Sonriendo Se Puede Ganar},
publisher = {MDPI},
keywords = {Boron Neutron Capture Therapy},
keywords = {Relative biological effectiveness},
keywords = {Thermal neutrons},
title = {Thermal Neutron Relative Biological Effectiveness Factors for Boron Neutron Capture Therapy from In Vitro Irradiations},
doi = {10.3390/cells9102144},
author = {Pedrosa-Rivera, María and Praena Rodríguez, Antonio Javier and Porras Sánchez, José Ignacio and Sabariego Quintanilla, Manuel and Álvarez, Patricia and Ruiz Ruiz, María Carmen and Ruiz Magaña, María José},
}